炎症性肠病中抗酿酒酵母抗体的IgG亚类

IgG subclasses of anti Saccharomyces cerevisiae antibody in inflammatory bowel disease.

作者信息

Oshitani N, Hato F, Jinno Y, Sawa Y, Nakamura S, Matsumoto T, Seki S, Kitagawa S, Arakawa T

机构信息

Third Department of Internal Medicine, Osaka City University Medical School, 1-4-3, asahi-machi, abeno-ku, Osaka 545-8585, Japan.

出版信息

Eur J Clin Invest. 2001 Mar;31(3):221-5. doi: 10.1046/j.1365-2362.2001.00798.x.

DOI:10.1046/j.1365-2362.2001.00798.x

PMID:11264649

Abstract

Elevation of serum anti Saccharomyces cerevisiae antibody (ASCA) has been reported in patients with Crohn's disease. We analysed the subclasses of Immunoglobulin (Ig) G reaction in ASCA in sera from patients with inflammatory bowel disease, healthy controls, and patients with intestinal Behçet's disease. Serum samples were obtained from 29 patients with Crohn's disease, 30 patients with ulcerative colitis, 7 patients with intestinal Behçet's disease, and 12 healthy controls. Serum IgG subclasses IgG1, IgG2, IgG3, and IgG4 of ASCA were analysed using ELISA. IgG4 ASCA was significantly increased in patients with inflammatory bowel disease. In patients with intestinal Behçet's disease, IgG1, IgG3, and IgG4 ASCA were increased. Differential responses, in terms of subclasses in ASCA, were found in patients with inflammatory bowel disease and patients with intestinal Behçet's disease, which may represent different pathophysiologies of these intestinal inflammatory diseases.

摘要

据报道，克罗恩病患者血清抗酿酒酵母抗体（ASCA）水平会升高。我们分析了炎症性肠病患者、健康对照者及肠道白塞病患者血清中ASCA的免疫球蛋白（Ig）G反应亚类。血清样本取自29例克罗恩病患者、30例溃疡性结肠炎患者、7例肠道白塞病患者及12名健康对照者。采用酶联免疫吸附测定法（ELISA）分析ASCA的血清IgG亚类IgG1、IgG2、IgG3和IgG4。炎症性肠病患者的IgG4 ASCA显著升高。肠道白塞病患者的IgG1、IgG3和IgG4 ASCA升高。在炎症性肠病患者和肠道白塞病患者中发现了ASCA亚类的不同反应，这可能代表了这些肠道炎症性疾病不同的病理生理学特征。