脂氧化酶对过敏反应慢反应物质（SRS-A）的灭活作用。
Inactivation of slow reacting substance of anaphylaxis (SRS-A) by lipoxidase.
作者信息
Sirois P
出版信息
Prostaglandins. 1979 Mar;17(3):395-404. doi: 10.1016/s0090-6980(79)80007-6.
PMID:112651
Abstract
Lipoxidase (E.C.1.13.1.13) inactivates rat SRS-A. The inactivation is time, temperature, and concentration-dependent. Linoleic acid and eicosatetraynoic acid inhibit the enzymatic deactivation of the mediator. It is concluded that SRS-A is a genuine substrate for lipoxidase and contains a cis, cis-1, 4-pentadiene structure. It is suggested that lipoxidase could play a major role in tissue removal of the mediator during hypersensitivity reactions.
摘要
脂氧化酶（E.C.1.13.1.13）可使大鼠慢反应物质A（SRS-A）失活。这种失活具有时间、温度和浓度依赖性。亚油酸和二十碳四烯酸可抑制该介质的酶促失活。结论是SRS-A是脂氧化酶的真正底物，且含有顺式、顺式-1,4-戊二烯结构。有人提出脂氧化酶在超敏反应期间对该介质的组织清除过程中可能起主要作用。
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