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脂氧化酶对过敏反应慢反应物质（SRS-A）的灭活作用。

Inactivation of slow reacting substance of anaphylaxis (SRS-A) by lipoxidase.

作者信息

Sirois P

出版信息

Prostaglandins. 1979 Mar;17(3):395-404. doi: 10.1016/s0090-6980(79)80007-6.

DOI:10.1016/s0090-6980(79)80007-6
PMID:112651
Abstract

Lipoxidase (E.C.1.13.1.13) inactivates rat SRS-A. The inactivation is time, temperature, and concentration-dependent. Linoleic acid and eicosatetraynoic acid inhibit the enzymatic deactivation of the mediator. It is concluded that SRS-A is a genuine substrate for lipoxidase and contains a cis, cis-1, 4-pentadiene structure. It is suggested that lipoxidase could play a major role in tissue removal of the mediator during hypersensitivity reactions.

摘要

脂氧化酶（E.C.1.13.1.13）可使大鼠慢反应物质A（SRS-A）失活。这种失活具有时间、温度和浓度依赖性。亚油酸和二十碳四烯酸可抑制该介质的酶促失活。结论是SRS-A是脂氧化酶的真正底物，且含有顺式、顺式-1,4-戊二烯结构。有人提出脂氧化酶在超敏反应期间对该介质的组织清除过程中可能起主要作用。

相似文献

1
Inactivation of slow reacting substance of anaphylaxis (SRS-A) by lipoxidase.脂氧化酶对过敏反应慢反应物质（SRS-A）的灭活作用。
Prostaglandins. 1979 Mar;17(3):395-404. doi: 10.1016/s0090-6980(79)80007-6.
2
Further evidence on the structure of slow reacting substance of anaphylaxis (SRS-A).关于过敏反应迟缓反应物质（SRS-A）结构的进一步证据。
Agents Actions. 1979 Oct;9(4):337-43. doi: 10.1007/BF01970658.
3
Further studies on the inactivation of slow-reacting substance of anaphylaxis by lipoxidase.关于脂氧化酶对过敏反应慢反应物质失活作用的进一步研究。
Adv Prostaglandin Thromboxane Res. 1980;6:125-8.
4
Effect of the 5-hydroperoxide of eicosatetraenoic acid and inhibitors of the lipoxygenase pathway on the formation of slow reacting substance by rat basophilic leukemia cells; direct evidence that slow reacting substance is a product of the lipoxygenase pathway.二十碳四烯酸5-氢过氧化物及脂氧合酶途径抑制剂对大鼠嗜碱性白血病细胞形成慢反应物质的影响；慢反应物质是脂氧合酶途径产物的直接证据。
J Immunol. 1980 Jul;125(1):163-8.
5
From slow reacting substance of anaphylaxis (SRS-A) to leukotriene D4 (LTD4).从过敏反应慢反应物质（SRS-A）到白三烯D4（LTD4）。
Int J Immunopharmacol. 1980;2(4):281-93. doi: 10.1016/0192-0561(80)90028-4.
6
Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis.花生四烯酸代谢调节剂对过敏反应慢反应物质合成与释放的影响。
Br J Pharmacol. 1979 Jan;65(1):35-41. doi: 10.1111/j.1476-5381.1979.tb17331.x.
7
The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release.脂肪酸氢过氧化物增强过敏介质释放的机制。
Prostaglandins. 1978 Aug;16(2):179-87. doi: 10.1016/0090-6980(78)90020-5.
8
Role of arachidonic acid in the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea pig lung fragments: evidence that SRS-A is very similar or identical structurally to nonimmunologically induced forms of SRS.花生四烯酸在致敏豚鼠肺组织碎片合成过敏反应慢反应物质（SRS-A）中的作用：有证据表明SRS-A在结构上与非免疫诱导形式的SRS非常相似或相同。
J Immunol. 1980 Aug;125(2):946-55.
9
Inhibition by non-steroid anti-inflammatory agents of rabbit aorta contracting activity generated in blood by slow reacting substance C.非甾体抗炎药对慢反应物质C在血液中产生的兔主动脉收缩活性的抑制作用。
Br J Pharmacol. 1974 Apr;50(4):543-51. doi: 10.1111/j.1476-5381.1974.tb08587.x.
10
Release of slow-reacting substance of anaphylaxis from dispersed pig lung cells: effect of cyclo-oxygenase and lipoxygenase inhibitors.从分散的猪肺细胞中释放过敏反应慢反应物质：环氧化酶和脂氧化酶抑制剂的作用。
J Allergy Clin Immunol. 1981 Jun;67(6):426-34. doi: 10.1016/0091-6749(81)90095-6.

引用本文的文献

1
Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.白三烯C和D结构类似物的收缩活性：疏水区域的必要性。
Proc Natl Acad Sci U S A. 1981 May;78(5):3195-8. doi: 10.1073/pnas.78.5.3195.
2
Leukotrienes: a new approach to the biochemistry of hypersensitivity.白三烯：过敏反应生物化学的新研究方向。
Surv Immunol Res. 1982;1(3):279-85. doi: 10.1007/BF02918470.
3
Chemical studies on slow reacting substances/leukotrienes.慢反应物质/白三烯的化学研究
Experientia. 1982 Nov 15;38(11):1259-75. doi: 10.1007/BF01954913.