花生四烯酸代谢调节剂对过敏反应慢反应物质合成与释放的影响。
Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis.
作者信息
Burka J F, Flower R J
出版信息
Br J Pharmacol. 1979 Jan;65(1):35-41. doi: 10.1111/j.1476-5381.1979.tb17331.x.
Abstract
1 Slow-reacting substance of anaphylaxis (SRS-A) was released in the peritoneum of passively sensitized rats challenged with ovalbumin and from rat isolated peritoneal cells stimulated with calcium ionophore A23187. 2 Both monocytes (macrophages) and mast cells appear to be involved in the synthesis and release of SRS-A. 3 The immunological release of SRS-A in vivo is enhanced by indomethacin and inhibited by dexamethasone, mepacrine, 1-phenyl-3-pyrazolidone (1-P-3-P), and methylimidazole. 4 SRS-A release induced by A23187 in vitro is inhibited by dexamethasone, indomethacin 1-P-3-P, eicosatetraynoic acid (ETA) and 15-hydroperoxy arachidonic acid. The inhibition induced by dexamethasone, indomethacin and 1-P-3-P is reduced by an increase in the calcium concentration from 1 mM to 5 mM, whereas the inhibition induced by ETA is increased. 5 The results suggest that a lipoxygenase is important in the synthesis and release by SRS-A.
摘要
- 用卵清蛋白攻击被动致敏大鼠的腹膜以及用钙离子载体A23187刺激大鼠分离的腹膜细胞时，会释放过敏反应慢反应物质（SRS-A）。2. 单核细胞（巨噬细胞）和肥大细胞似乎都参与了SRS-A的合成与释放。3. 吲哚美辛可增强体内SRS-A的免疫释放，而地塞米松、米帕林、1-苯基-3-吡唑啉酮（1-P-3-P）和甲基咪唑则可抑制该释放。4. 地塞米松、吲哚美辛、1-P-3-P、二十碳四烯酸（ETA）和15-氢过氧花生四烯酸可抑制A23187在体外诱导的SRS-A释放。当钙浓度从1 mM增加到5 mM时，地塞米松、吲哚美辛和1-P-3-P所诱导的抑制作用会减弱，而ETA所诱导的抑制作用则会增强。5. 结果表明，脂氧合酶在SRS-A的合成与释放过程中起重要作用。
相似文献
1
Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis.花生四烯酸代谢调节剂对过敏反应慢反应物质合成与释放的影响。
Br J Pharmacol. 1979 Jan;65(1):35-41. doi: 10.1111/j.1476-5381.1979.tb17331.x.
2
Release of slow-reacting substance of anaphylaxis from dispersed pig lung cells: effect of cyclo-oxygenase and lipoxygenase inhibitors.从分散的猪肺细胞中释放过敏反应慢反应物质：环氧化酶和脂氧化酶抑制剂的作用。
J Allergy Clin Immunol. 1981 Jun;67(6):426-34. doi: 10.1016/0091-6749(81)90095-6.
3
4
Mechanism of inhibitory action of tranilast on the release of slow reacting substance of anaphylaxis (SRS-A) in vitro: effect of tranilast on the release of arachidonic acid and its metabolites.曲尼司特对体外过敏反应慢反应物质（SRS-A）释放的抑制作用机制：曲尼司特对花生四烯酸及其代谢产物释放的影响。
Jpn J Pharmacol. 1988 Jan;46(1):53-60. doi: 10.1254/jjp.46.53.
5
Non-immunological release of slow-reacting substance from guinea-pig lungs.豚鼠肺中慢反应物质的非免疫性释放。
Br J Pharmacol. 1979 Sep;67(1):67-72.
6
Stimulation of arachidonic acid metabolism by human slow-reacting substances.人慢反应物质对花生四烯酸代谢的刺激作用。
Eur J Pharmacol. 1978 Nov 1;52(1):125-8. doi: 10.1016/0014-2999(78)90030-4.
7
Role of arachidonic acid in the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea pig lung fragments: evidence that SRS-A is very similar or identical structurally to nonimmunologically induced forms of SRS.花生四烯酸在致敏豚鼠肺组织碎片合成过敏反应慢反应物质（SRS-A）中的作用：有证据表明SRS-A在结构上与非免疫诱导形式的SRS非常相似或相同。
J Immunol. 1980 Aug;125(2):946-55.
8
Slow reacting substance of anaphylaxis (SRS-A) release from guinea-pig lung parenchyma during antigen- or ionophore-induced contraction.在抗原或离子载体诱导的收缩过程中，豚鼠肺实质中过敏反应慢反应物质（SRS-A）的释放。
J Pharmacol Exp Ther. 1982 Apr;221(1):146-51.
9
Release of mediators of anaphylaxis: inhibition of prostaglandin synthesis and the modification of release of slow reacting substance of anaphylaxis and histamine.过敏反应介质的释放：前列腺素合成的抑制以及过敏反应慢反应物质和组胺释放的改变。
Br J Pharmacol. 1978 Jan;62(1):61-6. doi: 10.1111/j.1476-5381.1978.tb07006.x.
10
Arachidonic acid metabolism and modulation of in vitro anaphylaxis by 5,8,11,14-eicosatetraynoic acid and 9a,12a-octadecadiynoic acid.花生四烯酸代谢以及5,8,11,14-二十碳四炔酸和9a,12a-十八碳二炔酸对体外过敏反应的调节作用
Br J Pharmacol. 1981 Apr;72(4):689-95. doi: 10.1111/j.1476-5381.1981.tb09150.x.
引用本文的文献
1
Effect of inhibition of arachidonic acid metabolism on anaphylaxis of guinea pig lung strips.抑制花生四烯酸代谢对豚鼠肺条过敏反应的影响。
Agents Actions. 1980 Jun;10(3):274-8. doi: 10.1007/BF02025947.
2
On the preparation of highly purified slow reacting substance of anaphylaxis (SRS-A) from biological extracts.关于从生物提取物中制备高纯度过敏反应迟缓反应物质（SRS-A）
Br J Pharmacol. 1980 Jan;68(1):33-46. doi: 10.1111/j.1476-5381.1980.tb10696.x.
3
Prostaglandins, thromboxanes and the pregnant rat uterus at term.前列腺素、血栓素与足月妊娠大鼠子宫
Br J Pharmacol. 1981 May;73(1):75-80. doi: 10.1111/j.1476-5381.1981.tb16773.x.
4
SRS-A mediated bronchospasm by pharmacologic modification of lung anaphylaxis in vivo.SRS-A 通过对体内肺过敏反应进行药理学修饰介导支气管痉挛。
Agents Actions. 1981 Jul;11(4):396-401. doi: 10.1007/BF01982477.
5
[Increase of pulmonary vascular resistance and permeability due to the metabolism of free arachidonic acid (author's transl)].游离花生四烯酸代谢导致肺血管阻力和通透性增加（作者译）
Klin Wochenschr. 1981 May 4;59(9):459-61. doi: 10.1007/BF01695900.
6
Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep.甲泼尼龙对绵羊内毒素血症后肺血管通透性增加的预防作用
J Clin Invest. 1981 Apr;67(4):1103-10. doi: 10.1172/jci110123.
7
An in vivo model for measuring antigen-induced SRS-A-mediated bronchoconstriction and plasma SRS-A levels in the guinea-pig.一种用于测量豚鼠体内抗原诱导的慢反应物质A介导的支气管收缩和血浆慢反应物质A水平的体内模型。
Br J Pharmacol. 1983 Jan;78(1):67-74. doi: 10.1111/j.1476-5381.1983.tb09363.x.
8
The effect of Ro 21-7634 on the antigen-induced production of bronchoconstrictive arachidonic acid metabolites in the guinea pig lung.Ro 21-7634对豚鼠肺中抗原诱导的支气管收缩性花生四烯酸代谢产物生成的影响。
Agents Actions. 1982 Oct;12(4):438-42. doi: 10.1007/BF01965923.
9
The pharmacology of isamoxole [2-methyl-n-butyl-n(4-methyloxazol-2-yl) propanamide] LRCL 3950, a new anti-allergic compound.异沙唑[2-甲基-n-丁基-n(4-甲基恶唑-2-基)丙酰胺]LRCL 3950的药理学，一种新型抗过敏化合物。
Br J Pharmacol. 1980;71(2):387-98. doi: 10.1111/j.1476-5381.1980.tb10951.x.
10
Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung.环氧化酶抑制对豚鼠肺组织碎片中抗原和离子载体诱导的慢反应物质释放的不同作用
Br J Pharmacol. 1984 Aug;82(4):871-6. doi: 10.1111/j.1476-5381.1984.tb16484.x.
本文引用的文献
1
The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.过敏性休克期间组胺的释放及慢反应物质（SRS-A）的形成。
J Physiol. 1960 Jun;151(3):416-35. doi: 10.1113/jphysiol.1960.sp006449.
2
Evidence for enzymatic histamine release from isolated rat mast cells.从分离的大鼠肥大细胞中酶促释放组胺的证据。
Exp Cell Res. 1961 Feb;23:45-57. doi: 10.1016/0014-4827(61)90062-3.
3
A sensitive method for the assay of 5-hydroxytryptamine.一种测定5-羟色胺的灵敏方法。
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9. doi: 10.1111/j.1476-5381.1957.tb00146.x.
4
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
5
Antigen-induced release of slow reacting substance of anaphylaxis (SRS-A rat) in rats prepared with homologous antibody.在制备了同源抗体的大鼠中，抗原诱导的过敏反应慢反应物质（SRS-A大鼠）的释放。
J Exp Med. 1968 Apr 1;127(4):767-82. doi: 10.1084/jem.127.4.767.
6
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.前列腺素内过氧化物。人血小板中花生四烯酸的新转化。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3400-4. doi: 10.1073/pnas.71.9.3400.
7
Histamine release in vitro: inhibition by catecholamines and methylxanthines.体外组胺释放：儿茶酚胺和甲基黄嘌呤的抑制作用
Science. 1968 Aug 30;161(3844):902-3. doi: 10.1126/science.161.3844.902.
8
Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines.前列腺素、一种前列腺素代谢产物、慢反应物质和组胺从过敏性肺组织中的释放，以及儿茶酚胺对其的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1974;284(3):279-93. doi: 10.1007/BF00500347.
9
In vivo and in vitro production of a slow reacting substance in the rat upon treatment with calcium ionophores.用钙离子载体处理大鼠后，大鼠体内和体外产生慢反应物质。
J Immunol. 1974 Dec;113(6):2040-4.
10
Basophil activation by concanavalin A: characteristics of the reaction.伴刀豆球蛋白A介导的嗜碱性粒细胞激活：反应特征
J Immunol. 1974 Jun;112(6):2117-25.
Zotero 插件