Saunders D R, Hedges J R, Sillery J, Esther L, Matsumura K, Rubin C E
Gastroenterology. 1975 May;68(5 Pt 1):1236-45.
By correlating morphological observations with quantitative measurements of net water transport, we determined whether bile salts altered colonic absorptive cells. Epithelial alteration was equivocal and water absorption was uninhibited during infusions of 1 mM deoxycholate or of concentrations of taurocholate less than 10 mM. In contrast, 3 mM deoxycholate and greater than 10 mM taurocholate caused severe altertion of colonic epithelium and inhibited water absorption. These studies suggest that bile salts in the low concentrations normally found within the colon have little effect on colonic structure or water absorption. On the other hand, abnormally high concentrations of bile salts do alter colonic mucosal structure and function.
通过将形态学观察结果与净水分运输的定量测量结果相关联，我们确定了胆盐是否会改变结肠吸收细胞。在输注1 mM脱氧胆酸盐或浓度低于10 mM的牛磺胆酸盐期间，上皮细胞改变不明确，水分吸收也未受抑制。相比之下，3 mM脱氧胆酸盐和高于10 mM的牛磺胆酸盐会导致结肠上皮细胞严重改变并抑制水分吸收。这些研究表明，结肠内通常发现的低浓度胆盐对结肠结构或水分吸收影响很小。另一方面，异常高浓度的胆盐确实会改变结肠黏膜结构和功能。
