Mata J M, Kershenobich D, Villarreal E, Rojkind M
Gastroenterology. 1975 May;68(5 Pt 1):1265-9.
Serum free proline and free hydroxyproline were determined in 71 patients with liver disease and in 62 control subjects. The group with liver disease included 60 patients with liver cirrhosis and 11 with chronic active liver disease. Forty-five of the cirrhotic patients were alcoholics, 9 of which were studied during an episode of alcoholic hepatitis. The control group consisted of 24 healthy volunteers, 19 primary malnourished patients, and 19 severely ill patients without liver disease. The values obtained in normal subjects were quite constant; no differences related to sex or age were detected. In patients with malnutrition, and especially in severely ill patients, the proline values were always below the normal limit. Patients with nonalcoholic cirrhosis or chronic active liver disease had serum proline and hydroxyproline values similar to those of normal subjects. However, the patients with alcoholic liver cirrhosis had proline and hydroxyproline values significantly higher than the normal group. Furthermore, in patients with alcoholic hepatitis the serum free proline values were significantly higher than in the other groups. The results suggest that alcohol might have a direct effect on proline metabolism or facilitate its release from the liver cell.
对71例肝病患者和62例对照者测定了血清游离脯氨酸和游离羟脯氨酸。肝病组包括60例肝硬化患者和11例慢性活动性肝病患者。45例肝硬化患者为酗酒者，其中9例在酒精性肝炎发作期间接受研究。对照组由24名健康志愿者、19例原发性营养不良患者和19例无肝病的重症患者组成。正常受试者测得的值相当稳定；未检测到与性别或年龄相关的差异。在营养不良患者中，尤其是重症患者，脯氨酸值总是低于正常范围。非酒精性肝硬化或慢性活动性肝病患者的血清脯氨酸和羟脯氨酸值与正常受试者相似。然而，酒精性肝硬化患者的脯氨酸和羟脯氨酸值明显高于正常组。此外，酒精性肝炎患者的血清游离脯氨酸值明显高于其他组。结果表明，酒精可能对脯氨酸代谢有直接影响，或促进其从肝细胞中释放。
