Model.it：根据序列数据构建三维DNA模型。
Model.it: building three dimensional DNA models from sequence data.
作者信息
Vlahovicek K, Pongor S
机构信息
Protein Structure and Function Group, International Centre for Genetic Engineering and Biotechnology, Area Science Park, 34012 Trieste, Italy.
出版信息
Bioinformatics. 2000 Nov;16(11):1044-5. doi: 10.1093/bioinformatics/16.11.1044.
UNLABELLED
A WWW server is described for creating 3D models of canonical or bent DNA starting from sequence data. Predicted DNA trajectory is first computed based on a choice of di- and tri-nucleotide models (M.G. Munteanu et al., Trends Biochem. Sci. 23, 341-347, 1998); an atomic model is then constructed and optionally energy-minimized with constrained molecular dynamics. The data are presented as a standard PDB file, directly viewable on the user's PC using any molecule manipulation program.
AVAILABILITY
The model.it server is freely available at http://www.icgeb.trieste.it/dna/
CONTACT
kristian@icgeb.trieste.it; pongor@icgeb.trieste.it
SUPPLEMENTARY INFORMATION
a series of help files is available at the above address.
未标注
描述了一种万维网服务器，用于从序列数据创建标准或弯曲DNA的三维模型。首先根据二核苷酸和三核苷酸模型的选择计算预测的DNA轨迹（M.G. 蒙特亚努等人，《生物化学趋势》23，341 - 347，1998年）；然后构建原子模型，并可选择使用约束分子动力学进行能量最小化。数据以标准的PDB文件形式呈现，可使用任何分子操作程序在用户的个人电脑上直接查看。
可用性
model.it服务器可在http://www.icgeb.trieste.it/dna/免费获取。
联系方式
kristian@icgeb.trieste.it；pongor@icgeb.trieste.it
补充信息
上述地址提供一系列帮助文件。
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