Ma J S, Chen P Y, Chen C H, Chi C S
Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, ROC.
J Microbiol Immunol Infect. 2000 Dec;33(4):267-70.
Hansenula anomala, an ascosporogenous yeast of the class Ascomycetes, is a free-living organism isolated from the environment. It is also a part of the normal or transient flora of the human throat and alimentary tract. It has been recognized as an opportunistic pathogen and its infection is very rare. A premature infant, a victim of right femoral osteomyelitis and right hip arthritis caused by oxacillin-resistant Staphylococcus aureus, was found to have developed H. anomala fungemia just before the initiation of the antimicrobial therapy with teicoplanin. Antifungal agents (fluconazole and amphotericin B) were prescribed for 10 days despite the absence of clinical sign of systemic fungal infection. His general condition remained good, with a subsequent sterile blood culture. The patient was discharged after completing 5 weeks of antimicrobial therapy, and he remained well during follow-up at our outpatient clinics. Here, we also review the risk factors, the clinical presentations, and the therapeutic strategies of H. anomala infection in the literature.
异常汉逊酵母是子囊菌纲的一种产子囊孢子酵母，是从环境中分离出的一种自由生活的生物体。它也是人类咽喉和消化道正常或短暂菌群的一部分。它已被确认为机会致病菌，其感染非常罕见。一名早产儿是耐苯唑西林金黄色葡萄球菌引起的右股骨骨髓炎和右髋关节关节炎患者，在开始使用替考拉宁进行抗菌治疗前被发现发生了异常汉逊酵母菌血症。尽管没有全身性真菌感染的临床症状，但仍给予抗真菌药物（氟康唑和两性霉素B）治疗10天。他的一般状况保持良好，随后血培养无菌。患者在完成5周的抗菌治疗后出院，在我们门诊随访期间情况良好。在此，我们还回顾了文献中异常汉逊酵母感染的危险因素、临床表现和治疗策略。
