Hartl D M, Hans S, Vaissière J, Riquet M, Laccourreye O, Brasnu D F
Voice, Biomaterials and Head and Neck Oncology, Research Laboratory, CNRS-UPRESA 7018, University Paris V, Georges Pompidou European Hospital, France.
Ann Otol Rhinol Laryngol. 2001 Mar;110(3):229-35. doi: 10.1177/000348940111000305.
This study was designed to objectively compare a patient's voice after onset of unilateral vocal fold paralysis (UVFP) to his or her own normal voice, and to compare the results after treatment by intrafold injection of autologous fat. Acoustic recordings were obtained for 2 male patients before thoracic surgery and after the onset of iatrogenic left UVFP. Vocal fold augmentation was performed 10 days after UVFP. The acoustic recordings were repeated within 3 days and at 1 month. The phonation quotient, pitch perturbation quotient, amplitude perturbation quotient, harmonics-to-noise ratio, cepstral peak prominence, and long-term average spectrum were analyzed. All parameters improved after treatment, with a return to preparalytic values for most. During the first month, some deterioration was noted. This is the first study comparing a subject's own normal voice to his or her voice after vocal fold augmentation. We recommend overinjection of fat if vocal fold atrophy is expected.
本研究旨在客观比较单侧声带麻痹（UVFP）发病后患者的嗓音与其自身正常嗓音，并比较自体脂肪声带内注射治疗后的结果。对2例男性患者在胸外科手术前及医源性左声带麻痹发病后进行声学记录。声带麻痹10天后进行声带填充。在3天内及1个月时重复进行声学记录。分析发声商、音高微扰商、振幅微扰商、谐波噪声比、谐波峰值突出度和长期平均谱。治疗后所有参数均有改善，大多数参数恢复到麻痹前的值。在第一个月期间，发现有一些恶化。这是第一项比较受试者自身正常嗓音与声带填充后嗓音的研究。如果预计有声带萎缩，我们建议过度注射脂肪。
