Montoro J, Valero A, Elices A, Rubira N, Serra-Baldrich E, Amat P, Malet A
Al-lergo Centre, Barcelona, Spain.
Allergol Immunopathol (Madr). 2000 Nov-Dec;28(6):332-3.
Sodium carboxymethylcellulose (SCMC) is the sodium salt of a polycarboxymethyl ether of cellulose. SCMC is widely used in pharmaceutical and food industries. We present the case of a 47-year-old man who suffered an anaphylactic shock after an intra-articular injection of Trigon depot.
Prick and intradermal tests with Trigon depot and its components (triamcinolone acetonide, Tween 80, benzylalcohol, SCMC), mepivacaine 2% and latex were performed. Challenge test with mepivacaine 2% was also realized.
Showed a positive intradermal test to Trigon depot and carboxymethylcellulose, with negative results to the rest (including challenge test to mepivcaine 2%).
Our results support the diagnosis of anaphylactic shock after intra-articular injection of carboxymethylcellulose and we consider necessary to emphasize that excipients must be taken into account as a potential source of adverse reactions to drugs.
羧甲基纤维素钠（SCMC）是纤维素的聚羧甲基醚的钠盐。SCMC在制药和食品工业中广泛使用。我们报告一例47岁男性在关节腔内注射曲安奈德长效混悬剂后发生过敏性休克的病例。
对曲安奈德长效混悬剂及其成分（曲安奈德、吐温80、苯甲醇、SCMC）、2%甲哌卡因和乳胶进行了点刺试验和皮内试验。还进行了2%甲哌卡因激发试验。
显示对曲安奈德长效混悬剂和羧甲基纤维素钠皮内试验呈阳性，其余结果均为阴性（包括2%甲哌卡因激发试验）。
我们的结果支持关节腔内注射羧甲基纤维素钠后过敏性休克的诊断，并且我们认为有必要强调辅料必须被视为药物不良反应的潜在来源。
