Alberty J, August C, Stoll W
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, Westfälische Wilhelms-Universität, Kardinal-von-Galen-Ring 10, 48129 Münster.
HNO. 2001 Feb;49(2):109-17. doi: 10.1007/s001060050719.
Oncocytic neoplasms of the salivary glands are rare.
PATIENTS/METHODS: We report on seven cases of oncocytic neoplasms of the parotid gland (one multifocal nodular oncocytic hyperplasia, five oncocytomas, and one oncocytic carcinoma).
While the history, clinical presentation, and histology of all oncocytic neoplasms showed no characteristic differences, intraoperatively the well-differentiated oncocytic carcinoma displayed an infiltrative, locally aggressive growth pattern. A local carcinoma recurring 7 years later corresponded to the primary tumor. There were no metastases. Immunohistochemistry revealed that all oncocytic neoplasms were positive for markers of cytokeratins (KI-1) and negative for markers of carcinoembryonal antigen (CEA), S-100 protein, and smooth muscle actin (SMA). In contrast to the benign neoplasms, the oncocytic carcinoma showed an increased rate of proliferating cells (MIB-1) and a strongly positive reaction with the antibody MA-903 against high molecular weight cytokeratins.
In a review of the literature, we could identify a group of locally aggressive, low-grade oncocytic carcinomas with a considerably better prognosis, similar to that of our case. The therapeutic significance of these findings is discussed.
涎腺嗜酸性细胞瘤罕见。
患者/方法：我们报告7例腮腺嗜酸性细胞瘤（1例多灶性结节性嗜酸性细胞增生、5例嗜酸性细胞瘤和1例嗜酸性细胞癌）。
虽然所有嗜酸性细胞瘤的病史、临床表现和组织学均无特征性差异，但术中高分化嗜酸性细胞癌表现为浸润性、局部侵袭性生长模式。7年后局部复发的癌与原发肿瘤一致。无转移。免疫组化显示，所有嗜酸性细胞瘤细胞角蛋白（KI-1）标记物阳性，癌胚抗原（CEA）、S-100蛋白和平滑肌肌动蛋白（SMA）标记物阴性。与良性肿瘤不同，嗜酸性细胞癌增殖细胞率（MIB-1）增加，且与抗高分子量细胞角蛋白抗体MA-903呈强阳性反应。
通过文献回顾，我们可以确定一组局部侵袭性、低级别嗜酸性细胞癌，其预后相当好，与我们的病例相似。讨论了这些发现的治疗意义。
