Pettet G J, McElwain D L, Norbury J
Centre in Statistical Science and Industrial Mathematics, School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia.
IMA J Math Appl Med Biol. 2000 Dec;17(4):395-413.
In this paper we consider a simple two species model for the growth of new blood vessels. The model is based upon the Lotka-Volterra system of predator and prey interaction, where we identify newly developed capillary tips as the predator species and a chemoattractant which directs their motion as the prey. We extend the Lotka-Volterra system to include a one-dimensional spatial dependence, by allowing the predators to migrate in a manner modelled on the phenomenon of chemotaxis. A feature of this model is its potential to support travelling wave solutions. We emphasize that in order to determine the existence of such travelling waves it is essential that the global relationships of a number of phase plane features other than the equilibria be investigated.
在本文中,我们考虑一个关于新血管生长的简单双物种模型。该模型基于捕食者与猎物相互作用的洛特卡 - 沃尔泰拉系统,其中我们将新形成的毛细血管尖端视为捕食者物种,将引导其运动的化学引诱剂视为猎物。我们通过允许捕食者以趋化现象为模型的方式迁移,将洛特卡 - 沃尔泰拉系统扩展为包含一维空间依赖性。该模型的一个特点是它有可能支持行波解。我们强调,为了确定此类行波的存在,研究除平衡点之外的许多相平面特征的全局关系至关重要。