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Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.非洲爪蟾中FGF家族新成员XFGF - 20的特性分析
Biochem Biophys Res Commun. 1999 Aug 11;261(3):756-65. doi: 10.1006/bbrc.1999.1039.
2
Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain.在胎儿脑中表达的新型人类成纤维细胞生长因子FGF-19的结构与表达
Biochim Biophys Acta. 1999 Jan 18;1444(1):148-51. doi: 10.1016/s0167-4781(98)00255-3.
3
The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer.成纤维细胞生长因子-1（FGF-1）和成纤维细胞生长因子受体-1（FGFR-1）在人乳腺癌中的表达与定位
Clin Immunol Immunopathol. 1998 Oct;89(1):28-34. doi: 10.1006/clin.1998.4551.
4
Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.小鼠胚胎中三个高度相关基因Fgf8、Fgf17和Fgf18表达的比较。
Mech Dev. 1998 Jun;74(1-2):175-7. doi: 10.1016/s0925-4773(98)00061-6.
5
Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain.一种新的成纤维细胞生长因子FGF - 17的结构与表达，该因子在胚胎脑中优先表达。
Biochem Biophys Res Commun. 1998 Mar 6;244(1):187-91. doi: 10.1006/bbrc.1998.8239.
6
Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family.成纤维细胞生长因子家族新成员FGF-16的结构与表达
Biochem Biophys Res Commun. 1998 Feb 4;243(1):148-52. doi: 10.1006/bbrc.1998.8073.
7
A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1.一种在发育中的神经系统中表达的新型成纤维细胞生长因子基因是嵌合型同源结构域癌蛋白E2A-Pbx1的下游靶点。
Development. 1997 Sep;124(17):3221-32. doi: 10.1242/dev.124.17.3221.
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Structure and expression of human fibroblast growth factor-10.人成纤维细胞生长因子-10的结构与表达
J Biol Chem. 1997 Sep 12;272(37):23191-4. doi: 10.1074/jbc.272.37.23191.
9
Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart.小鼠成纤维细胞生长因子-12和成纤维细胞生长因子-13：在胚胎神经系统、结缔组织和心脏中的表达。
Mech Dev. 1997 Jun;64(1-2):31-9. doi: 10.1016/s0925-4773(97)00042-7.
10
Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues.成纤维细胞生长因子受体（FGFR）多基因家族在正常成人组织中的差异表达。
J Histochem Cytochem. 1997 Jul;45(7):1005-19. doi: 10.1177/002215549704500710.

酸性成纤维细胞生长因子（aFGF）和成纤维细胞生长因子受体4（FGFR4）在乳腺纤维腺瘤中的表达

Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas.

作者信息

La Rosa S, Sessa F, Colombo L, Tibiletti M G, Furlan D, Capella C

机构信息

Division of Pathology, Ospedale di Circolo, I-21100 Varese, Italy.

出版信息

J Clin Pathol. 2001 Jan;54(1):37-41. doi: 10.1136/jcp.54.1.37.

DOI:10.1136/jcp.54.1.37
PMID:11271786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1731265/
Abstract

BACKGROUND/AIM: Fibroadenomas are benign tumours composed of both glandular and fibrous tissue. The mechanisms regulating the growth of these tumours and the relation between the stromal and epithelial cells are poorly understood. Acidic fibroblast growth factor (aFGF) is a well known fibroblast activator, which acts through four specific cell surface receptors, among which, fibroblast growth factor receptor 4 (FGFR4) is highly specific. The aim of this study was to evaluate the distribution of aFGF and FGFR4 in specific cell types of fibroadenomas to understand their possible role in the growth of these breast lesions.

METHODS

Formalin fixed and paraffin wax embedded tissues from 15 fibroadenomas and peritumoral normal breasts were investigated for the expression of aFGF and FGFR4 using immunohistochemistry. The presence of aFGF mRNA was also investigated using in situ hybridisation.

RESULTS

Immunoreactivity for aFGF and FGFR4 was seen in epithelial cells, but it was lacking in myoepithelial cells of both normal tissues and fibroadenomas. Strong FGFR4 immunoreactivity was found in stromal fibroblasts, which were also weakly positive for aFGF. aFGF mRNA was detected in epithelial cells and in some stromal fibroblasts.

CONCLUSIONS

These results suggest a paracrine/autocrine modulation of epithelial and stromal cells of fibroadenomas through an aFGF-FGFR4 interaction. This interaction might regulate various cell functions and the growth of fibroadenomas.

摘要

背景/目的：纤维腺瘤是由腺组织和纤维组织构成的良性肿瘤。目前对这些肿瘤生长的调控机制以及基质细胞与上皮细胞之间的关系了解甚少。酸性成纤维细胞生长因子（aFGF）是一种众所周知的成纤维细胞激活剂，它通过四种特定的细胞表面受体发挥作用，其中成纤维细胞生长因子受体4（FGFR4）具有高度特异性。本研究的目的是评估aFGF和FGFR4在纤维腺瘤特定细胞类型中的分布，以了解它们在这些乳腺病变生长中可能发挥的作用。

方法

采用免疫组织化学方法，对15例纤维腺瘤及瘤旁正常乳腺组织的福尔马林固定石蜡包埋组织进行aFGF和FGFR4表达的检测。同时采用原位杂交法检测aFGF mRNA的表达情况。

结果

在正常组织和纤维腺瘤的上皮细胞中均可见aFGF和FGFR4的免疫反应性，但肌上皮细胞中未见。在基质成纤维细胞中发现强FGFR4免疫反应性，这些细胞对aFGF也呈弱阳性。在上皮细胞和一些基质成纤维细胞中检测到aFGF mRNA。

结论

这些结果提示，纤维腺瘤的上皮细胞和基质细胞通过aFGF-FGFR4相互作用进行旁分泌/自分泌调节。这种相互作用可能调节多种细胞功能及纤维腺瘤的生长。