Gupta Monica, Palta Anshu, Singh Ram, Lehl Sarabmeet Singh
Department of Medicine, Government Medical College and Hospital, Chandigarh, India.
Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
J Midlife Health. 2014 Apr;5(2):72-7. doi: 10.4103/0976-7800.133991.
Evidence from various epidemiological and clinical studies suggests that iron overload is proinflammatory and proatherosclerotic. Excess body iron has been positively associated with insulin resistance, type 2 diabetes and obesity.
To study the relationship of body iron stores with type 2 diabetes and obesity in middle aged North Indian population.
The participant population consisted of four groups of randomly selected participants (between 40 and 65 years of age and postmenopausal women); Group A: Normal individuals (controls), Group B: Obese nondiabetic individuals, Group C: Lean diabetic patients, Group D: Obese diabetic patients. Blood was examined for hematological, biochemical estimations, C-reactive protein, and serum ferritin (SF).
A total of 197 participants were enrolled. The mean SF levels (ng/ml) among males were: Group A (n = 18) 148.56 ± 119.90; Group B (n = 25) 129.11 ± 94.77; Group C (n = 27) 127.96 ± 109.65 and Group D (n = 22) 148.36 ± 104.94. The mean SF levels (ng/ml) among females were: Group A (n = 23) 67.44 ± 37.59; Group B (n = 25) 59.62 ± 43.56; Group C (n = 24) 77.97 ± 91.46 and Group D (n = 33) 66.46 ± 86.05. No statistical difference was found among the groups in both the sexes.
Our observation is in sharp contrast to the earlier studies published from the West stressing that iron stores are increased in obesity and diabetes. We conclude that SF may not be a strong risk factor in the pathogenesis of obesity and diabetes in middle aged North Indians.
来自各种流行病学和临床研究的证据表明，铁过载具有促炎和促动脉粥样硬化作用。体内铁过量与胰岛素抵抗、2型糖尿病和肥胖呈正相关。
研究印度北部中年人群体内铁储存与2型糖尿病和肥胖之间的关系。
参与人群由四组随机选择的参与者组成（年龄在40至65岁之间的绝经后女性）；A组：正常个体（对照组），B组：肥胖非糖尿病个体，C组：消瘦糖尿病患者，D组：肥胖糖尿病患者。对血液进行血液学、生化指标、C反应蛋白和血清铁蛋白（SF）检测。
共招募了197名参与者。男性的平均SF水平（ng/ml）为：A组（n = 18）148.56 ± 119.90；B组（n = 25）129.11 ± 94.77；C组（n = 27）127.96 ± 109.65；D组（n = 22）148.36 ± 104.94。女性的平均SF水平（ng/ml）为：A组（n = 23）67.44 ± 37.59；B组（n = 25）59.62 ± 43.56；C组（n = 24）77.97 ± 91.46；D组（n = 33）66.46 ± 86.05。两组性别之间均未发现统计学差异。
我们的观察结果与西方早期发表的强调肥胖和糖尿病中铁储存增加的研究形成鲜明对比。我们得出结论，SF可能不是印度北部中年人群肥胖和糖尿病发病机制中的强风险因素。
