Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka University.
J Epidemiol. 2012;22(6):484-93. doi: 10.2188/jea.je20120006. Epub 2012 Sep 15.
We investigated the relationship between dietary iron intake and mortality from cardiovascular disease (CVD) in a population-based sample of Japanese adults.
The study cohort consisted of 58 615 healthy Japanese (23 083 men and 35 532 women), aged between 40 and 79 years, who had no history of stroke, coronary heart disease (CHD), or cancer at baseline. Dietary iron intake was assessed at baseline by a validated food frequency questionnaire administered between 1988 and 1990 as part of the Japan Collaborative Cohort (JACC) Study.
We documented 2690 (1343 men and 1347 women) deaths from CVD: 1227 (607 men and 620 women) deaths from total stroke, 651 from ischemic stroke (355 men and 296 women), 459 (196 men and 263 women) from hemorrhagic stroke, and 557 (311 men and 246 women) from CHD. Dietary intake of total iron was positively associated with mortality from total and ischemic stroke and total CVD in men. The multivariable hazard ratio for the highest versus the lowest quintile of total iron intake was 1.43 (95% CI, 1.02-2.00; P for trend = 0.009) for total stroke and 1.27 (1.01-1.58; 0.023) for total CVD in men. Dietary total iron intake was not associated with mortality from other endpoints in men, and was not associated with any endpoints in women.
Dietary intake of total iron was positively associated with mortality from stroke and total CVD in Japanese men.
我们在一项基于人群的日本成年人样本中研究了膳食铁摄入量与心血管疾病（CVD）死亡率之间的关系。
研究队列包括 58615 名健康的日本成年人（23083 名男性和 35532 名女性），年龄在 40 至 79 岁之间，基线时无卒中、冠心病（CHD）或癌症病史。膳食铁摄入量在基线时通过 1988 年至 1990 年期间作为日本合作队列研究（JACC 研究）一部分进行的验证后的食物频率问卷进行评估。
我们记录了 2690 例（1343 名男性和 1347 名女性）CVD 死亡：1227 例（607 名男性和 620 名女性）死于总卒中，651 例死于缺血性卒中（355 名男性和 296 名女性），459 例（196 名男性和 263 名女性）死于出血性卒中，557 例（311 名男性和 246 名女性）死于 CHD。男性总铁摄入量与总卒中和缺血性卒中以及总 CVD 死亡率呈正相关。最高与最低五分位数总铁摄入量的多变量危险比为 1.43（95%CI，1.02-2.00；趋势 P 值=0.009），用于总卒中，1.27（1.01-1.58；0.023），用于总 CVD。男性膳食总铁摄入量与其他终点的死亡率无关，与女性任何终点均无关。
日本男性膳食总铁摄入量与卒中和总 CVD 死亡率呈正相关。
