Vuksan V, Sievenpiper J L, Wong J, Xu Z, Beljan-Zdravkovic U, Arnason J T, Assinewe V, Stavro M P, Jenkins A L, Leiter L A, Francis T
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto.
Am J Clin Nutr. 2001 Apr;73(4):753-8. doi: 10.1093/ajcn/73.4.753.
We previously showed that 3 g American ginseng administered 40 min before an oral glucose challenge significantly reduces postprandial glycemia in subjects without diabetes. Whether this effect can be replicated with doses <3 g and administration times closer to the oral glucose challenge is unclear.
Our objective was to study the dosing and timing effects of American ginseng on postprandial glycemia.
In a random crossover design, 12 healthy individuals [X +/- SEM age: 42 +/- 7 y; body mass index (BMI; in kg/m2): 24.1 +/- 1.1] received 16 treatments: 0 (placebo), 1, 2, or 3 g American ginseng at 40, 20, 10, or 0 min before a 25-g oral glucose challenge. Capillary blood was collected before administration and at 0, 15, 30, 45, 60, and 90 min after the start of the glucose challenge.
Two-way analysis of variance showed that the main effects of treatment and administration time were significant (P < 0.05). Glycemia was lower over the last 45 min of the test after doses of 1, 2, or 3 g ginseng than after placebo (P < 0.05); there were no significant differences between doses. The reductions in the areas under the curve for these 3 doses were 14.4 +/- 6.5%, 10.6 +/- 4.0%, and 9.1 +/- 6%, respectively. Glycemia in the last hour of the test and area under the curve were significantly lower when ginseng was administered 40 min before the challenge than when it was administered 20, 10, or 0 min before the challenge (P < 0.05).
American ginseng reduced postprandial glycemia in subjects without diabetes. These reductions were time dependent but not dose dependent: an effect was seen only when the ginseng was administered 40 min before the challenge. Doses within the range of 1-3 g were equally effective.
我们之前的研究表明，在口服葡萄糖耐量试验前40分钟服用3克西洋参，可显著降低非糖尿病受试者的餐后血糖水平。尚不清楚服用剂量小于3克且给药时间更接近口服葡萄糖耐量试验时，这种效果是否能够重现。
我们的目的是研究西洋参对餐后血糖的给药剂量和给药时间的影响。
采用随机交叉设计，12名健康个体[年龄（X±SEM）：42±7岁；体重指数（BMI，单位：kg/m2）：24.1±1.1]接受16种处理：在25克口服葡萄糖耐量试验前40、20、10或0分钟服用0（安慰剂）、1、2或3克西洋参。在给药前以及葡萄糖耐量试验开始后的0、15、30、45、60和90分钟采集毛细血管血。
双向方差分析显示，处理因素和给药时间的主效应具有显著性（P<0.05）。服用1、2或3克人参后，试验最后45分钟的血糖水平低于服用安慰剂后（P<0.05）；各剂量之间无显著差异。这3个剂量的曲线下面积减少分别为14.4±6.5%、10.6±4.0%和9.1±6%。在试验前40分钟服用人参时，试验最后一小时的血糖水平和曲线下面积显著低于在试验前20、10或0分钟服用人参时（P<0.05）。
西洋参可降低非糖尿病受试者的餐后血糖水平。这些降低是时间依赖性的，而非剂量依赖性：仅在试验前40分钟服用人参时可见效果。1 - 3克范围内的剂量效果相同。
