Cury J A, Hashizume L N, Del Bel Cury A A, Tabchoury C P
Faculty of Dentistry of Piracicaba, State University of Campinas, S.P., Brazil.
Caries Res. 2001 Mar-Apr;35(2):106-10. doi: 10.1159/000047440.
The additive effect of baking soda on the anticariogenic effect of fluoride dentifrice is not well established. To evaluate it, a crossover in situ study was done in three phases of 28 days. Volunteers, using acrylic palatal appliances containing four human enamel blocks, two sound (to evaluate demineralization) and two with artificial caries lesions (to evaluate remineralization), took part in this study. During each phase, 10% sucrose solution was dripped (3 times a day) only onto the sound blocks. After 10 min, a slurry of placebo, fluoride (F) or fluoride and baking soda (F+NaHCO(3)) dentifrice was dripped onto all enamel blocks. The results showed a higher F concentration in dental plaque formed during treatment with F+NaHCO(3) than placebo (p<0.05), but the difference related to F dentifrice was not significant. The enamel demineralization was lower, and remineralization was greater, after treatment with F+NaHCO(3) than placebo (p<0.05), but the difference related to F dentifrice was not significant. The data suggest that baking soda neither improves nor impairs the effect of F dentifrice on reduction of demineralization and enhancement of remineralization of enamel.
小苏打对含氟牙膏防龋效果的增效作用尚未明确。为评估其效果，开展了一项为期28天、分三个阶段的交叉原位研究。志愿者使用含有四块人牙釉质块的丙烯酸腭部矫治器参与本研究，其中两块完好（用于评估脱矿），两块有人造龋损（用于评估再矿化）。在每个阶段，仅向完好的牙釉质块上滴注10%蔗糖溶液（每天3次）。10分钟后，将安慰剂、含氟（F）或含氟和小苏打的牙膏（F+NaHCO₃）浆液滴注到所有牙釉质块上。结果显示，与安慰剂相比，F+NaHCO₃治疗期间形成的牙菌斑中氟浓度更高（p<0.05），但与含氟牙膏相比差异不显著。与安慰剂相比，F+NaHCO₃治疗后牙釉质脱矿程度更低，再矿化程度更高（p<0.05），但与含氟牙膏相比差异不显著。数据表明，小苏打既不会增强也不会削弱含氟牙膏对减少牙釉质脱矿和增强再矿化的效果。
