Nobre-dos-Santos Marinês, Rodrigues Lidiany K A, Del-Bel-Cury Altair A, Cury Jaime A
Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil.
J Oral Sci. 2007 Jun;49(2):147-54. doi: 10.2334/josnusd.49.147.
Since the anticaries effect of a dentifrice with low fluoride concentration and low pH is unknown, the aim of the present study was to evaluate in situ the enamel remineralizing ability of this type of formulation. A double-blind crossover design employing 3 phases of 45 days was conducted. Six adult volunteers wore palatal devices containing 6 previously demineralized human dental enamel slabs, which were subjected 3 times a day to one of the following treatments: non-fluoridated dentifrice (negative control); dentifrice containing 1, 100 microg F/g, pH 7.0 (positive control); dentifrice containing 550 microg F/g, pH 5.5 (experimental). At the end of each phase, enamel remineralization was assessed in terms of cross-sectional microhardness, and loosely as well as firmly bound fluoride formation was determined on the enamel surface. Fluoridated dentifrices were more effective than the negative control in forming loosely and firmly bound fluoride on enamel (P < 0.05). However, the positive control formed more loosely bound fluoride than the other treatments (P < 0.05). Microhardness analysis showed that the fluoridated dentifrices were more effective than the negative control (P < 0.05) in remineralizing dental enamel, although no statistically significant difference was observed between them. Thus, the experimental dentifrice was shown to be effective in remineralizing dental enamel, and this may be attributable to its ability to form firmly bound fluoride on enamel.
由于低氟浓度和低pH值牙膏的防龋效果尚不清楚，本研究旨在原位评估这类配方的牙釉质再矿化能力。采用了一个双盲交叉设计，包括3个为期45天的阶段。6名成年志愿者佩戴腭部装置，其中含有6块预先脱矿的人牙釉质板，每天对其进行3次以下处理之一：不含氟的牙膏（阴性对照）；含氟量为1100μg F/g、pH值为7.0的牙膏（阳性对照）；含氟量为550μg F/g、pH值为5.5的牙膏（实验组）。在每个阶段结束时，根据横断面显微硬度评估牙釉质再矿化情况，并测定牙釉质表面松散结合和牢固结合的氟化物形成情况。含氟牙膏在牙釉质上形成松散结合和牢固结合的氟化物方面比阴性对照更有效（P<0.05）。然而，阳性对照形成的松散结合氟化物比其他处理更多（P<0.05）。显微硬度分析表明，含氟牙膏在使牙釉质再矿化方面比阴性对照更有效（P<0.05），尽管它们之间未观察到统计学上的显著差异。因此，实验性牙膏被证明在使牙釉质再矿化方面是有效的，这可能归因于其在牙釉质上形成牢固结合氟化物的能力。
