Tungtrongchitr R, Pongpaew P, Phonrat B, Tribunyatkul S, Viroonudomphol D, Supawan V, Jintaridhi P, Lertchavanakul A, Vudhivai N, Schelp F P
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Rajthevee, Bangkok 10400, Thailand.
Int J Vitam Nutr Res. 2001 Jan;71(1):74-81. doi: 10.1024/0300-9831.71.1.74.
The weight, height, body mass index (BMI), waist/hip ratio, serum leptin and lipid profiles of 48 overweight (BMI > or = 25.00). Thai males and 166 overweight Thai females, compared with 26 males and 81 females in a control group (BMI = 18.5-24.9 kg/m2), were investigated. Subjects for the study were those persons who turned up regularly for physical check-ups at the out-patient department, general practice section of the Rajvithi Hospital, Bangkok. The study was conducted between March-October, 1998. Statistically significantly higher levels of serum leptin, cholesterol, LDL-C, LDL-C/HDL-C ratio and triglyceride were found in the overweight compared with the control subjects. The median serum leptin concentration in overweight subjects was 19.6 (2.0-60.0 ng/ml) compared with 9.0 (range 1.0-30.0 ng/ml) in the control subjects (p < 0.001). The median values of leptin serum concentrations in the overweight and obese males were significantly higher than those of the overweight and obese females. A total of 66.7% (32 out of 48) of the overweight and obese males had elevated leptin levels, while elevated leptin levels were found in 87.3% (145 out of 166) of the overweight and obese females. A total of 18.8% and 21.1% of the overweight and obese males and females respectively had cholesterol concentrations of > or = 6.48 mmol/l. However, the prevalence of low HDL-C (HDL-C < or = 0.91 mmol/l) was found to be 41.7% in the overweight and obese males and 4.2% in the overweight and obese females. Statistically significant associations were found between weight, height, BMI, waist, hip, waist/hip ratio, HDL-C, and serum leptin in both overweight male and female subjects. A negative correlation was found between serum leptin and LDL-C/HDL-C ratio in both the overweight and obese subjects.
对48名超重（体重指数[BMI]≥25.00）的泰国男性和166名超重的泰国女性，与对照组的26名男性和81名女性（BMI=18.5-24.9kg/m²）的体重、身高、体重指数、腰臀比、血清瘦素和血脂谱进行了调查。研究对象是那些定期到曼谷拉吉维提医院门诊普通科进行体检的人。该研究于1998年3月至10月进行。与对照组相比，超重者血清瘦素、胆固醇、低密度脂蛋白胆固醇（LDL-C）、LDL-C/高密度脂蛋白胆固醇（HDL-C）比值和甘油三酯水平在统计学上显著更高。超重者血清瘦素浓度中位数为19.6（2.0-60.0ng/ml），而对照组为9.0（范围1.0-30.0ng/ml）（p<0.001）。超重和肥胖男性的瘦素血清浓度中位数显著高于超重和肥胖女性。超重和肥胖男性中共有66.7%（48人中的32人）瘦素水平升高，而超重和肥胖女性中有87.3%（166人中的145人）瘦素水平升高。超重和肥胖男性和女性中分别有18.8%和21.1%的人胆固醇浓度≥6.48mmol/l。然而，超重和肥胖男性中低HDL-C（HDL-C≤0.91mmol/l）的患病率为41.7%，超重和肥胖女性中为4.2%。在超重的男性和女性受试者中，体重、身高、BMI、腰围、臀围、腰臀比、HDL-C和血清瘦素之间存在统计学上的显著关联。在超重和肥胖受试者中，血清瘦素与LDL-C/HDL-C比值之间均呈负相关。
