Tungtrongchitr Rungsunn, Pongpaew Praneet, Tongboonchoo Chuthaporn, Vudhivai Niyomsri, Changbumrung Supranee, Tungtrongchitr Anchalee, Phonrat Benjaluck, Viroonudomphol Duangkamol, Pooudong Somchai, Schelp Frank Peter
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University.
Int J Vitam Nutr Res. 2003 Feb;73(1):8-14. doi: 10.1024/0300-9831.73.1.8.
This study investigated levels of serum homocysteine, vitamin B12, folic acid, vitamin B6 and vitamin C, in 37 male and 112 female overweight and obese Thai volunteers (body mass index; BMI > or = 25.00), and 23 male and 90 female normal-weight Thai volunteers, who came for a physical check-up at the Out-patient Department, General Practice Section, Rajvithi Hospital, Bangkok from March to October of 2000. Data included anthropometric measurements and waist/hip ratios. All anthropometric variables, except height, were significantly higher for the overweight subjects than for the normal subjects. Statistically significantly higher levels of serum homocysteine were found in the overweight subjects. Serum homocysteine concentrations in overweight and obese males were significantly higher than in overweight and obese females. Serum folic acid and vitamin C in the overweight and obese were found to be statistically significantly lower than in the control subjects. No statistically significant difference in vitamin B12 was found in the overweight and obese subjects compared with the normal control subjects. The medians of serum folic acid and vitamin C concentrations for the overweight and obese males were significantly lower than those of the overweight and obese females. A negative correlation was found between serum folic acid and homocysteine concentrations in all overweight and obese subjects. A significant negative correlation between serum folic acid and vitamin B6 was observed in both male and female overweight and obese subjects. The results of the investigation suggest that homocysteine levels in overweight and obese subjects seem to be caused by insufficient dietary folic acid intake and probably not by B12 deficiency.
本研究调查了2000年3月至10月期间，在曼谷拉吉维蒂医院全科门诊前来进行体检的37名男性和112名女性泰国超重及肥胖志愿者（体重指数；BMI≥25.00），以及23名男性和90名女性泰国正常体重志愿者的血清同型半胱氨酸、维生素B12、叶酸、维生素B6和维生素C水平。数据包括人体测量指标和腰臀比。除身高外，所有人体测量变量在超重受试者中均显著高于正常受试者。超重受试者的血清同型半胱氨酸水平在统计学上显著更高。超重及肥胖男性的血清同型半胱氨酸浓度显著高于超重及肥胖女性。超重及肥胖者的血清叶酸和维生素C在统计学上显著低于对照组。与正常对照受试者相比，超重及肥胖受试者的维生素B12未发现统计学上的显著差异。超重及肥胖男性的血清叶酸和维生素C浓度中位数显著低于超重及肥胖女性。在所有超重及肥胖受试者中，血清叶酸和同型半胱氨酸浓度之间呈负相关。在男性和女性超重及肥胖受试者中，均观察到血清叶酸和维生素B6之间存在显著负相关。调查结果表明，超重及肥胖受试者的同型半胱氨酸水平似乎是由膳食叶酸摄入不足引起的，而可能不是由维生素B12缺乏引起的。
