Medina D, Hazlewood C F, Cleveland G G, Chang D C, Spjut H J, Moyers R
J Natl Cancer Inst. 1975 Apr;54(4):813-8.
The ability of nuclear magnetic resonance (NMR) spectroscopy to distinguish normal, diseased non-neoplastic, and neoplastic human breast tissues was investigated with T1 and T2 relaxation times used. The results indicated that NMR relaxation times could distinguish between the mean values of breast neoplasms and other diseased or normal tissues, with P values less than 0.001. Given a single sample, the probability of classifying it nonneoplastic or carcinoma could be accomplished with 85% confidence. For human breast tissues, the relaxation time T2 may be more discriminating that T1. These results support the view that the use of NMR spectroscopy in cancer detection may be of significant value and warrants considerable more interest and effort to determine the beneficial applications and limits of this technology.
利用T1和T2弛豫时间研究了核磁共振（NMR）光谱区分正常、非肿瘤性病变和肿瘤性人类乳腺组织的能力。结果表明，NMR弛豫时间能够区分乳腺肿瘤与其他病变或正常组织的平均值，P值小于0.001。对于单个样本，以85%的置信度可以完成将其分类为非肿瘤性或癌性的概率。对于人类乳腺组织，弛豫时间T2可能比T1更具鉴别力。这些结果支持这样一种观点，即在癌症检测中使用NMR光谱可能具有重要价值，值得更多的关注和努力来确定该技术的有益应用和局限性。
