Jezernik M, Sentjurc M, Schara M
Acta Neurochir (Wien). 1983;67(1-2):1-9. doi: 10.1007/BF01401662.
A series of different human brain tumours have been characterized with respect to the proton spin-lattice relaxation time (T1) and the water content. In malignant tumour tissue the mean T1 values are significantly larger than in benign ones. The tumours of different histological types showed notable differences in the relationship between proton relaxation rate (1/T1) and the corresponding water content (r). Malignant tumours exhibited a large variation in the water content in the presence of relatively small changes in relaxation rates, whilst just the opposite was true of the benign tumours and normal tissue. Taking into consideration the fast exchange between the intracellular and extracellular fluid, the (1/T1)/r relationship observed in malignant tissue is explainable by the variation in water content in the extracellular fluid due to oedema, which is most pronounced in malignant tumours. The individual response of patients to the malignant growth seems to determine the tissue water content and hence the measured relaxation time, whilst it appears that the relaxation rate and the water content of the malignant cells of the same tumour type do not vary appreciably from one patient to another. On the other hand, benign and non-tumourous tissue cells from different patients show larger variations in T1, whilst the variations in the extracellular water content are obviously smaller than in malignant tissues.
已经对一系列不同的人脑肿瘤在质子自旋 - 晶格弛豫时间（T1）和含水量方面进行了表征。在恶性肿瘤组织中，平均T1值明显大于良性肿瘤组织中的平均T1值。不同组织学类型的肿瘤在质子弛豫率（1/T1）与相应含水量（r）之间的关系上表现出显著差异。恶性肿瘤在弛豫率变化相对较小时含水量有很大变化，而良性肿瘤和正常组织则恰恰相反。考虑到细胞内液和细胞外液之间的快速交换，在恶性组织中观察到的（1/T1）/r关系可以通过水肿导致的细胞外液含水量变化来解释，这在恶性肿瘤中最为明显。患者对恶性生长的个体反应似乎决定了组织含水量，从而决定了测量的弛豫时间，而同一肿瘤类型的恶性细胞的弛豫率和含水量在不同患者之间似乎没有明显差异。另一方面，不同患者的良性和非肿瘤组织细胞的T1变化较大，而细胞外含水量的变化明显小于恶性组织。
