Eggleston J C, Saryan L A, Hollis D P
Cancer Res. 1975 May;35(5):1326-32.
A large number of samples of human neoplastic and abnormal nonneoplastic tissues were studied by nuclear magnetic resonance spectrometry in order to evaluate the possible role of this technique in the diagnosis of cancer. The spin-lattice magnetic relaxation times (T1) of abnormal nonneoplastic tissue were longer, in many instances, than those of malignant tumors from similar sites, preventing recognition of the tumors in this manner. The evidence for the nonspecific nature of the prolongation of T1 in abnormal tissue is reviewed, and additional limitations of this technique in the diagnosis of cancer are indicated.
为了评估核磁共振光谱技术在癌症诊断中可能发挥的作用，对大量人类肿瘤性和异常非肿瘤性组织样本进行了研究。在许多情况下，异常非肿瘤性组织的自旋晶格磁弛豫时间（T1）比来自相似部位的恶性肿瘤的弛豫时间更长，这使得无法通过这种方式识别肿瘤。本文回顾了异常组织中T1延长的非特异性本质的证据，并指出了该技术在癌症诊断中的其他局限性。
