使用促性腺激素释放激素激动剂对外阴复发性侵袭性血管黏液瘤进行初步药物治疗。
Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist.
作者信息
Fine B A, Munoz A K, Litz C E, Gershenson D M
机构信息
North Texas Gynecologic Oncology, Dallas, Texas 75251, USA.
出版信息
Gynecol Oncol. 2001 Apr;81(1):120-2. doi: 10.1006/gyno.2000.6119.
BACKGROUND
An aggressive angiomyxoma of the pelvis is a locally infiltrative lesion treated with wide local excision. Recurrence is common. A potential medical treatment alternative is reported.
CASE
A 34-year-old woman presented with her second recurrence of a vulvar angiomyxoma following two prior surgical excisions. Analysis of the recurrent tumor for estrogen and progesterone receptors was strongly positive. The patient was treated with 3 months of a gonadotropin-releasing hormone (GnRH) agonist. Comparison of pre- and posttreatment magnetic resonance imaging scans showed complete radiographic resolution of the tumor. Physical examination confirmed these findings.
CONCLUSION
Medical management with a GnRH agonist may obviate the need for radical exenterative surgery for a recurrent aggressive angiomyxoma of the vulva.
背景
盆腔侵袭性血管黏液瘤是一种需行广泛局部切除治疗的局部浸润性病变。复发很常见。本文报道了一种潜在的药物治疗方案。
病例
一名34岁女性，在外阴血管黏液瘤经两次手术切除后出现第二次复发。对复发性肿瘤的雌激素和孕激素受体分析呈强阳性。该患者接受了3个月的促性腺激素释放激素（GnRH）激动剂治疗。治疗前和治疗后的磁共振成像扫描对比显示肿瘤在影像学上完全消退。体格检查证实了这些结果。
结论
使用GnRH激动剂进行药物治疗可能避免对外阴复发性侵袭性血管黏液瘤进行根治性手术切除。
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