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通往有丝分裂的叉状路径。

The fork'ed path to mitosis.

作者信息

Jorgensen P, Tyers M

机构信息

Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada M5G 1X5.

出版信息

Genome Biol. 2000;1(3):REVIEWS1022. doi: 10.1186/gb-2000-1-3-reviews1022. Epub 2000 Sep 15.

DOI:10.1186/gb-2000-1-3-reviews1022
PMID:11277966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC138864/
Abstract

A concurrence of genomic, reverse genetic and biochemical approaches has cracked the decade-long enigma concerning the identity of the transcription factors that control gene expression at the G2/M transition in the budding yeast cell cycle.

摘要

基因组学、反向遗传学和生物化学方法的结合,解开了长达十年的谜团,即关于在芽殖酵母细胞周期中控制G2/M转换期基因表达的转录因子的身份之谜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e107/138864/cd509e34aa40/gb-2000-1-3-reviews1022-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e107/138864/93b35c2102e5/gb-2000-1-3-reviews1022-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e107/138864/cd509e34aa40/gb-2000-1-3-reviews1022-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e107/138864/93b35c2102e5/gb-2000-1-3-reviews1022-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e107/138864/cd509e34aa40/gb-2000-1-3-reviews1022-2.jpg

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本文引用的文献

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Whither genomics?基因组学何去何从?
Genome Biol. 2000;1(1):COMMENT003. doi: 10.1186/gb-2000-1-1-comment003. Epub 2000 Jun 9.
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Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase.叉头转录因子Fkh1p和Fkh2p与Mcm1p协同作用,以控制M期所需的转录。
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The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF.叉头蛋白Fkh2是酵母细胞周期转录因子SFF的一个组成部分。
Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks.
揭示叉头蛋白介导的酵母细胞周期和代谢网络调控机制。
Comput Struct Biotechnol J. 2022 Apr 7;20:1743-1751. doi: 10.1016/j.csbj.2022.03.033. eCollection 2022.
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Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex.叉头转录因子 Fkh1:深入了解功能调节域对于 Sin3 组蛋白去乙酰化酶复合物招募的关键作用。
Curr Genet. 2021 Jun;67(3):487-499. doi: 10.1007/s00294-021-01158-3. Epub 2021 Feb 26.
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Genome-wide role of codon usage on transcription and identification of potential regulators.全基因组范围内密码子使用对转录的作用及潜在调控因子的鉴定。
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A Clb/Cdk1-mediated regulation of Fkh2 synchronizes expression in the budding yeast cell cycle.Clb/Cdk1介导的Fkh2调控使芽殖酵母细胞周期中的表达同步。
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PLoS Comput Biol. 2016 Dec 9;12(12):e1005230. doi: 10.1371/journal.pcbi.1005230. eCollection 2016 Dec.
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Response to hyperosmotic stress.对高渗胁迫的反应。
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