Charbonnier V, Morrison B M, Paye M, Maibach H I
Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94143-0989, USA.
Food Chem Toxicol. 2001 Mar;39(3):279-86. doi: 10.1016/s0278-6915(00)00132-0.
Compared to exaggerated hand washing procedures, an open non-exaggerated assay better approximates consumer surfactant use. Our goal was to observe skin surface modifications induced by an open test with regard to discriminating between surfactant solutions. This human in vivo assay provided information about the effect of only three washes at the laboratory and a week of at-home use. Dorsal hand and volar forearm were compared. The results demonstrated that this clinical model permits exploration of subclinical surfactant-induced irritation. Both the volar forearm and the dorsal hand are capable of discriminating between the effects of sodium lauryl sulfate (SLS) and sodium laureth sulfate (SLES). Squamometry proved to be a sensitive assessment technique for detecting surfactant-induced subclinical skin surface alterations and for differentiating surfactant effects in this open application assay, in as few as three washes.
与夸张的洗手程序相比，开放式非夸张检测方法更接近消费者使用表面活性剂的实际情况。我们的目标是通过开放式测试观察皮肤表面的变化，以便区分不同的表面活性剂溶液。这项人体体内检测在实验室仅进行三次清洗，并在家中使用一周后，提供了相关效果信息。对受试者的手背和前臂掌侧进行了比较。结果表明，该临床模型可用于探索表面活性剂引起的亚临床刺激。前臂掌侧和手背都能够区分月桂醇硫酸酯钠（SLS）和月桂醇聚醚硫酸酯钠（SLES）的效果。在这项开放式应用检测中，鳞片测量法被证明是一种灵敏的评估技术，只需三次清洗，就能检测出表面活性剂引起的亚临床皮肤表面变化，并区分表面活性剂的效果。
