Pasini A, Belloni C
Divisione di Ostetricia e Ginecologia, Ospedale Valduce, Como, Italy.
Minerva Ginecol. 2001 Feb;53(1):13-20.
Complications due to hysteroscopy are relatively rare events. They occur more frequently with operative hysteroscopy than with diagnostic hysteroscopy. Exact complications rates are difficult to determine owing to the natural tendency to report successes but not complications. Recognition of these situations will lead to prevention; in fact, all the most serious complications of operative hysteroscopy can be avoided when proper precautions are taken and close communication is maintained among gynecologic surgeon, the anesthesiologist and nursing staff. The more clinically significant complications are: uterine perforation, haemorrhage and electrolyte imbalance.
Between January 1993 and December 1998, 697 women underwent operative hysteroscopy in our Department. Operative hysteroscopy was performed with continuous flow, high frequency resectoscope. Under general anesthesia the cervix was dilated to 10 mm and the uterine cavity was distended with 1.5% glycine solution or mannitol under 80 to 120 mmHg pressure. Resection with electrocoagulation was completed. The patients were submitted to the following procedures: 354 endometrial polypectomies (50.7%), 160 myomectomies (23%), 114 endometrial ablations (16.4%) and 69 hysteroscopic metroplasties (9.9%).
In our series complications occurred in 95 out of 697 patients (13.6%). The most important complications were: 12 (1.7%) uterine perforations, 48 (6.9%) intraoperative haemorrhages and 35 (5%) excessive hypotonic fluid absorptions. Four out of 12 perforations occurred during the dilation of the cervical channel. Since the distention of the uterine cavity could not be achieved, the procedures were stopped. No signs of vaginal or intraperitoneal haemorrhage were observed; 8 out of 12 perforations were due to the tip of the electrical source. The operative hysteroscopies were immediately stopped and the consequences were: 6 diagnostic laparoscopies, 1 laparotic hysterectomy (hemorrhage) and 1 laparotomy for thermal bowel injury. In 48 patients intraoperative bleeding could not be controlled with electrocautery. In these cases in the operating room a Foley catheter was inserted into the uterine cavity and the bulb inflated with 10 to 30 mL of liquid to tamponade the bleeding. The catheters were removed 12 to 24 hours later. No patients required blood transfusion. Excessive intravasation of electrolyte-free fluid occurred in 35 patients. Hyponatremia and hypokalemia (hypo-osmolarity result) were never serious. Headaches, nausea and vomiting were the most frequent symptoms of our patients. No cardiac arrhythmia, cerebral edema, brain herniation occurred. In our series, hemorrhage was the most common complication; intravasation and uterine perforation were at the second and the third place. Complications rates decreased progressively du to a better major training and experience of the surgeons. Also the curves of each complication show a significant decrease. Myomectomy in our hands has been the most dangerous procedure. However, serious sequelae were rare mainly for two reasons: we prefer stop the intervention rather than continue when a deficit of 1.000 mL is reached. Consequently, it is very important to discuss the possibility of incomplete resection of the endouterine lesion with the patient preoperatively; a protocol for fluid management in the operating room must be used for all the procedures (also the easiest) by all the surgeons and the nurses.
Our relatively high prevalence of intraoperative complications and distribution of the different types do not differ from the findings of published reports. In personal experience operative hysteroscopy is a safe surgical procedure for the treatment of endouterine abnormalities.
宫腔镜检查引起的并发症相对少见。与诊断性宫腔镜检查相比,手术宫腔镜检查时并发症更常发生。由于人们自然倾向于报告成功案例而非并发症,所以确切的并发症发生率难以确定。认识到这些情况将有助于预防;事实上,当采取适当预防措施并在妇科外科医生、麻醉师和护理人员之间保持密切沟通时,手术宫腔镜检查的所有最严重并发症都可以避免。临床上更重要的并发症有:子宫穿孔、出血和电解质失衡。
1993年1月至1998年12月期间,我科有697名女性接受了手术宫腔镜检查。手术宫腔镜检查采用连续灌流高频电切镜进行。在全身麻醉下,将宫颈扩张至10毫米,并用1.5%的甘氨酸溶液或甘露醇在80至120毫米汞柱的压力下扩张子宫腔。完成电凝切除。患者接受了以下手术:354例子宫内膜息肉切除术(50.7%)、160例子宫肌瘤切除术(23%)、114例子宫内膜切除术(16.4%)和69例宫腔镜子宫成形术(9.9%)。
在我们的系列研究中,697例患者中有95例发生并发症(13.6%)。最重要的并发症有:12例(1.7%)子宫穿孔、48例(6.9%)术中出血和35例(5%)低渗液体过量吸收。12例穿孔中有4例发生在宫颈管扩张过程中。由于无法实现子宫腔的扩张,手术停止。未观察到阴道或腹腔内出血迹象;12例穿孔中有8例是由电切镜尖端引起的。手术宫腔镜检查立即停止,后果如下:6例诊断性腹腔镜检查、1例剖腹子宫切除术(出血)和1例因热损伤肠道的剖腹手术。在48例患者中,术中出血无法用电灼控制。在这些情况下,在手术室将一根Foley导管插入子宫腔,球囊用10至30毫升液体充盈以压迫出血。导管在12至24小时后取出。没有患者需要输血。35例患者发生了无电解质液体的过量血管内灌注。低钠血症和低钾血症(低渗结果)从未严重过。头痛、恶心和呕吐是我们患者最常见的症状。未发生心律失常、脑水肿、脑疝。在我们的系列研究中,出血是最常见的并发症;血管内灌注和子宫穿孔分别位居第二和第三。由于外科医生的专业培训和经验更好,并发症发生率逐渐降低。而且每种并发症的曲线也显示出显著下降。在我们手中,子宫肌瘤切除术一直是最危险的手术。然而,严重后遗症很少见,主要有两个原因:当达到1000毫升的液体量不足时,我们宁愿停止手术而不是继续。因此,术前与患者讨论子宫内病变不完全切除的可能性非常重要;手术室的液体管理方案必须由所有外科医生和护士用于所有手术(即使是最简单的手术)。
我们术中并发症的相对高发生率和不同类型的分布与已发表报告的结果没有差异。根据个人经验,手术宫腔镜检查是治疗子宫内异常的一种安全的外科手术。