Zyss Tomasz, Mamczarz Jacek, Vetulani Jerzy
Department of Psychiatry, Medical College of the Jagellonian University.
Int J Neuropsychopharmacol. 1999 Mar;2(1):31-34. doi: 10.1017/S1461145799001339.
To assess the similarity of the behavioural effects of the rapid transcranial magnetic stimulation (rTMS) to those produced by other antidepressant treatments, in particular to repeated electroconvulsive shock (ECS), we carried out experiments on Wistar rats. The effects of a standard ECS procedure (9 daily treatments; the current parameters: 150 mA, 50 Hz, 0.5 s) were compared with 18 d treatment with rTMS of the same field intensity of 1.6 T but with different stimulation frequency (20 or 30 Hz) and a different number of sessions (9 or 18). Twenty-four hours after the last treatment the forced swimming test was carried out and the immobility time was recorded. The standard ECT reduced the immobility by 50%, the intensive rTMS (90 or 104 K impulses for the whole period of treatment) caused a significant effect, although smaller than that induced by ECT (reduction by 20-30%). The stimulation at 20 Hz required 18 treatment sessions to produce a significant effect, while only 9 sessions with stimulation at 30 Hz were sufficient to produce a comparable result. This suggests that the effectiveness of rTMS may be augmented by increasing the number or frequency of rTMS impulses.
为评估快速重复经颅磁刺激（rTMS）与其他抗抑郁治疗，尤其是重复电休克（ECS）所产生行为效应的相似性，我们对Wistar大鼠进行了实验。将标准ECS程序（每日治疗9次；电流参数：150 mA，50 Hz，0.5 s）的效应与1.6 T相同场强但不同刺激频率（20或30 Hz）以及不同疗程数（9或18）的rTMS治疗18天的效应进行比较。在最后一次治疗24小时后进行强迫游泳试验并记录不动时间。标准ECT使不动时间减少了50%，高强度rTMS（整个治疗期间90或104 K脉冲）产生了显著效果，尽管比ECT诱导的效果小（减少20 - 30%）。20 Hz刺激需要18个治疗疗程才能产生显著效果，而30 Hz刺激仅9个疗程就足以产生类似结果。这表明增加rTMS脉冲的数量或频率可能会增强rTMS的有效性。
