Deswal A, Misra A, Bozkurt B
Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Heart Fail Rev. 2001 Mar;6(2):143-51. doi: 10.1023/a:1011462011567.
The understanding of the role of "neurohormones" in the progression of heart failure has led to the utilization of agents that antagonize the activation of neurohormonal systems as effective therapy in patients with heart failure. As more evidence emerges linking proinflammatory cytokines to disease progression in heart failure, there is an increasing interest in developing anti-cytokine strategies that might be used as adjunctive therapy in patients with heart failure. Accordingly, the focus of the present review is to summarize the experimental and clinical studies that have attempted to modulate the effects of cytokines in heart failure. Strategies have been employed to either suppress cytokine production or to prevent their toxic effects by interfering with the binding of cytokines to their cognate receptors.
对“神经激素”在心力衰竭进展中作用的认识，促使人们将拮抗神经激素系统激活的药物用作心力衰竭患者的有效治疗手段。随着越来越多的证据表明促炎细胞因子与心力衰竭的疾病进展有关，人们对开发可能用作心力衰竭患者辅助治疗的抗细胞因子策略的兴趣日益浓厚。因此，本综述的重点是总结那些试图调节细胞因子在心力衰竭中作用的实验和临床研究。已采用多种策略，要么抑制细胞因子的产生，要么通过干扰细胞因子与其同源受体的结合来防止其毒性作用。
