Anderson T J
Southwest Foundation for Biomedical Research, San Antonio, TX, USA.
Trends Parasitol. 2001 Apr;17(4):183-8. doi: 10.1016/s1471-4922(00)01944-9.
Molecular markers are used widely to discriminate between closely related species of parasites, and in many cases a single locus is used for this purpose. This article aims to show how molecular data derived from a single genetic marker or linkage group - in this case mitochondrial DNA - can lead to ambiguous conclusions and to illustrate how a multilocus approach has enhanced our understanding of the epidemiology of two closely related parasites, the nematodes Ascaris suum, which infects pigs, and Ascaris lumbicoides, which infects humans.
分子标记被广泛用于区分亲缘关系密切的寄生虫物种，在许多情况下，单个基因座被用于此目的。本文旨在展示从单个遗传标记或连锁群（在本文中为线粒体DNA）获得的分子数据如何导致模糊的结论，并说明多位点方法如何增进了我们对两种亲缘关系密切的寄生虫——感染猪的线虫猪蛔虫和感染人类的线虫人蛔虫——流行病学的理解。
