Trinta K S, Liberto M I, de Paula V S, Yoshida C F, Gaspar A M
Departamento de Virologia, Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Mem Inst Oswaldo Cruz. 2001 Jan;96(1):25-9. doi: 10.1590/s0074-02762001000100004.
A retrospective study on the prevalence of hepatitis E virus (HEV) infection was conducted in selected populations in Rio de Janeiro, Brazil. A total of 1,115 subjects were tested including 146 patients with acute Non-A Non-B Non-C (NANBNC) viral hepatitis, 65 hemodialysis patients, 93 blood donors, 102 intravenous drug users (IVDUs), 304 pregnant women, 145 individuals living in the rural area and 260 individuals living in the urban area. In order to characterize a favorable epidemiological set for enterically transmitted infection in the studied populations we also evaluated the prevalence of anti-HAV IgG (hepatitis A virus) antibodies. Specific antibodies to HEV (anti-HEV IgG) were detected by a commercial EIA and specific antibodies to HAV (anti-HAV IgG) were detected using a competitive "in house" EIA. We found a high prevalence of anti-HAV IgG in these populations, that could indicate some risk for infections transmitted via the fecal-oral route. The anti-HEV IgG prevalence among the different groups were: 2.1% in patients with acute NANBNC viral hepatitis, 6.2% in hemodialysis patients, 4.3% in blood donors, 11.8% in IVDUs, 1% in pregnant women, and 2.1% in individuals form the rural area. Among individuals living in the urban area we did not find a single positive serum sample. Our results demonstrated the presence of anti-HEV IgG in almost all studied populations; however, further studies are necessary to establish the real situation of HEV epidemiology in Rio de Janeiro, Brazil.
在巴西里约热内卢的特定人群中开展了一项关于戊型肝炎病毒（HEV）感染率的回顾性研究。共检测了1115名受试者，包括146例急性非甲非乙非丙（NANBNC）病毒性肝炎患者、65名血液透析患者、93名献血者、102名静脉注射吸毒者（IVDU）、304名孕妇、145名农村居民和260名城市居民。为了确定所研究人群中肠道传播感染的有利流行病学情况，我们还评估了抗甲型肝炎病毒（HAV）IgG抗体的感染率。采用商业酶免疫测定法（EIA）检测抗HEV IgG特异性抗体，采用竞争性“内部”EIA检测抗HAV IgG特异性抗体。我们发现这些人群中抗HAV IgG的感染率很高，这可能表明存在经粪-口途径传播感染的一些风险。不同组中抗HEV IgG的感染率分别为：急性NANBNC病毒性肝炎患者中为2.1%，血液透析患者中为6.2%，献血者中为4.3%，IVDU中为11.8%，孕妇中为1%，农村居民中为2.1%。在城市居民中，我们未发现一份阳性血清样本。我们的结果表明，几乎所有研究人群中都存在抗HEV IgG；然而，有必要进一步开展研究以确定巴西里约热内卢戊型肝炎病毒流行病学的实际情况。
