巴西中部戈亚尼亚脆弱人群中的戊型肝炎流行情况。
Hepatitis E Prevalence in Vulnerable Populations in Goiânia, Central Brazil.
机构信息
Faculty of Nursing, Federal University of Goias, Goiania 74605-080, Brazil.
Institute of Tropical Medicine and Public Health, Federal University of Goias, Goiania 74605-050, Brazil.
出版信息
Viruses. 2023 Oct 10;15(10):2070. doi: 10.3390/v15102070.
A transversal study was conducted among 472 vulnerable individuals (recyclable waste pickers, immigrants and refugees, homeless individuals, as well as lesbian, gay, bisexual, and transexual individuals) in Goiânia City, the capital of the State of Goiás, Brazil, to investigate the prevalence of hepatitis E virus (HEV) infection. A total of 459 (97.2%) serum samples were tested for anti-HEV IgG and IgM antibodies using fully automated chemiluminescence immunoassays (Liaison Murex Anti-HEV IgG and IgM assays, DiaSorin, Saluggia, Italy). Positive samples were tested for the presence of HEV RNA by a real-time polymerase chain reaction. A seroprevalence of 0.87% (95% confidence interval [CI]: 0.34-2.22) was found for anti-HEV IgG. Furthermore, anti-HEV IgM was detected in only one individual (0.22%; 95% CI: 0.04-1.22), who was also negative for HEV RNA. These findings revealed that HEV infection is infrequent in vulnerable individuals in Central Brazil, with low seroprevalence of past and recent HEV infections.
一项横断面研究在巴西戈亚斯州首府戈亚尼亚市的 472 名脆弱个体（可回收废物拾荒者、移民和难民、无家可归者以及女同性恋、男同性恋、双性恋和跨性别者）中进行，旨在调查戊型肝炎病毒（HEV）感染的流行率。使用全自动化学发光免疫分析（Liaison Murex Anti-HEV IgG 和 IgM 分析，DiaSorin，Saluggia，意大利）检测了 459 份（97.2%）血清样本的抗-HEV IgG 和 IgM 抗体。通过实时聚合酶链反应检测阳性样本中 HEV RNA 的存在。抗-HEV IgG 的血清流行率为 0.87%（95%置信区间 [CI]：0.34-2.22）。此外，仅在一名个体（0.22%；95%CI：0.04-1.22）中检测到抗-HEV IgM，该个体也为 HEV RNA 阴性。这些发现表明，HEV 感染在巴西中部的脆弱个体中并不常见，过去和近期 HEV 感染的血清流行率较低。
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