Oleske J M, Westphal M L, Shore S, Gorden D, Bogden J D, Nahmias A
Am J Dis Child. 1979 Sep;133(9):915-8. doi: 10.1001/archpedi.1979.02130090043007.
A child with hypogammaglobulinemia and intractable diarrhea underwent parenteral alimentation for five months. A clinical syndrome of acrodermatitis enteropathica subsequently developed associated with a depression in thymus-dependent lymphocyte (T cell) numbers, abnormal T-cell mitogen-induced blast transformation, and anergy to skin test antigens. Plasma zinc levels were found to be abnormally low. Zinc therapy resulted in dramatic resolution of the clinical manifestations of acrodermatitis enteropathica. Cell-mediated immune function was also restored to normal, suggesting an important role for zinc and possibly other trace metals in cellular immune responses.
一名患有低丙种球蛋白血症和顽固性腹泻的儿童接受了五个月的胃肠外营养。随后出现了肠病性肢端皮炎的临床综合征，伴有胸腺依赖性淋巴细胞（T细胞）数量减少、T细胞有丝分裂原诱导的母细胞转化异常以及对皮肤试验抗原无反应。发现血浆锌水平异常低。锌治疗使肠病性肢端皮炎的临床表现显著缓解。细胞介导的免疫功能也恢复正常，表明锌以及可能其他微量金属在细胞免疫反应中起重要作用。
