Luypaert R, Boujraf S, Sourbron S, Osteaux M
MR-Centre, Academisch Ziekenhuis, Vrije Universiteít Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.
Eur J Radiol. 2001 Apr;38(1):19-27. doi: 10.1016/s0720-048x(01)00286-8.
Diffusion and perfusion MR imaging are now being used increasingly in neuro-vascular clinical applications. While diffusion weighted magnetic resonance imaging exploits the translational mobility of water molecules to obtain information on the microscopic behaviour of the tissues (presence of macromolecules, presence and permeability of membranes, equilibrium intracellular-extracellular water, ellipsis), perfusion weighted imaging makes use of endogenous and exogenous tracers for monitoring their hemodynamic status. The combination of both techniques is extremely promising for the early detection and assessment of stroke, for tumor characterisation and for the evaluation of neurodegenerative diseases. This article provides a brief review of the basic physics principles underlying the methodologies followed.
扩散加权磁共振成像（Diffusion-weighted magnetic resonance imaging，DWI）和灌注加权磁共振成像（Perfusion-weighted imaging，PWI）在神经血管临床应用中的使用越来越广泛。扩散加权磁共振成像利用水分子的平移运动来获取组织微观行为的信息（大分子的存在、膜的存在和通透性、细胞内外水平衡等），而灌注加权成像则使用内源性和外源性示踪剂来监测其血流动力学状态。这两种技术的结合对于中风的早期检测和评估、肿瘤特征的表征以及神经退行性疾病的评估极具前景。本文简要回顾了这些方法背后的基本物理原理。
