Farrell E R, Tosh G, Church E, Münsterberg A E
School of Life Sciences Biocentre, Division of Cell and Developmental Biology, University of Dundee, Wellcome Trust Biocenter, Dow Street, DD 1 5EH, Dundee, UK.
Mech Dev. 2001 Apr;102(1-2):227-30. doi: 10.1016/s0925-4773(01)00296-9.
In this study we describe cloning and expression of CSAL2, a second member of the spalt gene family in chick. All spalt proteins are characterized by the presence of multiple zinc-finger motifs, which are highly conserved. Mutations in HSAL1, a human spalt gene result in Townes-Brocks syndrome (TBS). We show here that CSAL2 is expressed in many of the tissues affected in TBS, including neural tissue, limb buds, mesonephros and cloaca.
在本研究中，我们描述了CSAL2的克隆和表达，CSAL2是鸡体内spalt基因家族的第二个成员。所有spalt蛋白的特征都是存在多个高度保守的锌指基序。人类spalt基因HSAL1的突变会导致汤姆斯-布罗克斯综合征（TBS）。我们在此表明，CSAL2在许多受TBS影响的组织中表达，包括神经组织、肢芽、中肾和泄殖腔。
