Kalyon B D, Olgun U
Highly Filled Materials Institute, Stevens Institute of Technology, Hoboken, New Jersey 07030, USA.
Am J Infect Control. 2001 Apr;29(2):124-5. doi: 10.1067/mic.2001.113229.
Triclosan (2, 4, 4'-trichloro-2'-hydroxydiphenyl ether) is a broad-spectrum antimicrobial agent, routinely used in various personal care products.(1) It is also incorporated into polymers through melt-mixing, with the aim of providing persistent antibacterial action on the surface of the polymer.(2,3) Such triclosan-incorporated polymers can be promoted for hospital use as fabric seat covers, tables, chairs, and clothing. We assessed the antibacterial efficacy of triclosan-incorporated polymer disks against 2 bacteria cultured in liquids in contact with the polymer. In spite of the relatively high concentrations of triclosan in the polymer, only some initial slowing of the bacterial growth rates was observed, followed by the absence of an antibacterial effect over extended periods. The triclosan at the surface of the disks dissolves into the liquids, and the rest of the triclosan, immobilized in the disks, does not contribute to the antibacterial effectiveness of triclosan-incorporated polymer. In light of recent studies, which have shown that triclosan acts on a specific target within the bacterial lipid synthesis pathway, triclosan-incorporated polymers may provide the ideal setting for resistant strains of bacteria to grow and thus should be used selectively in hospital environments.
三氯生（2,4,4'-三氯-2'-羟基二苯醚）是一种广谱抗菌剂，常用于各种个人护理产品中。（1）它还通过熔融共混被掺入聚合物中，目的是在聚合物表面提供持久的抗菌作用。（2,3）这种含三氯生的聚合物可作为织物座椅套、桌子、椅子和衣物推广用于医院。我们评估了含三氯生的聚合物圆盘对与聚合物接触的液体中培养的两种细菌的抗菌效果。尽管聚合物中三氯生的浓度相对较高，但仅观察到细菌生长速率有一些初始减缓，随后在较长时间内没有抗菌效果。圆盘表面的三氯生溶解到液体中，而固定在圆盘中的其余三氯生对含三氯生聚合物的抗菌效果没有贡献。鉴于最近的研究表明三氯生作用于细菌脂质合成途径中的特定靶点，含三氯生的聚合物可能为耐药菌株的生长提供理想环境，因此在医院环境中应选择性使用。
