Petersen Richard C
Department of Biomaterials and Restorative Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
AIMS Mol Sci. 2016;3(1):88-103. doi: 10.3934/molsci.2016.1.88. Epub 2016 Mar 29.
Triclosan antimicrobial molecular fluctuating energies of nonbonding electron pairs for the oxygen atom by ether bond rotations are reviewed with conformational computational chemistry analyses. Subsequent understanding of triclosan alternating ether bond rotations is able to help explain several material properties in Polymer Science. Unique bond rotation entanglements between triclosan and the polymer chains increase both the mechanical properties of polymer toughness and strength that are enhanced even better through secondary bonding relationships. Further, polymer blend compatibilization is considered due to similar molecular relationships and polarities. With compatibilization of triclosan in polymers a more uniform stability for nonpolar triclosan in the polymer solid state is retained by the antimicrobial for extremely low release with minimum solubility into aqueous solution. As a result, triclosan is projected for long extended lifetimes as an antimicrobial polymer additive. Further, triclosan rapid alternating ether bond rotations disrupt secondary bonding between chain monomers in the resin state to reduce viscosity and enhance polymer blending. Thus, triclosan is considered for a polymer additive with multiple properties to be an antimicrobial with additional benefits as a nonpolar toughening agent and a hydrophobic wetting agent. The triclosan material relationships with alternating ether bond rotations are described through a complete different form of medium by comparisons with known antimicrobial properties that upset bacterial cell membranes through rapid fluctuating mechanomolecular energies. Also, triclosan bond entanglements with secondary bonding can produce structural defects in weak bacterial lipid membranes requiring pliability that can then interfere with cell division. Regarding applications with polymers, triclosan can be incorporated by mixing into a resin system before cure, melt mixed with thermoplastic polymers that set on cooling into a solid or alternatively applied as a coating through several different methods with dissolving into an organic solvent and dried on by evaporation as a common means.
通过构象计算化学分析，综述了三氯生抗菌分子中氧原子非键电子对通过醚键旋转的波动能量。随后对三氯生交替醚键旋转的理解有助于解释高分子科学中的几种材料特性。三氯生与聚合物链之间独特的键旋转缠结增加了聚合物韧性和强度的机械性能，通过二次键合关系，这些性能得到了更好的增强。此外，由于分子关系和极性相似，考虑了聚合物共混物的增容作用。随着三氯生在聚合物中的增容，抗菌剂在聚合物固态中对非极性三氯生保持了更均匀的稳定性，使其极低释放，在水溶液中的溶解度最小。因此，三氯生作为一种抗菌聚合物添加剂预计具有较长的使用寿命。此外，三氯生快速交替的醚键旋转破坏了树脂状态下链单体之间的二次键合，从而降低了粘度并增强了聚合物共混。因此，三氯生被认为是一种具有多种性能的聚合物添加剂，它作为一种非极性增韧剂和疏水性湿润剂具有额外的益处。通过与已知的通过快速波动的机械分子能量破坏细菌细胞膜的抗菌性能进行比较，以一种完全不同的介质形式描述了三氯生与交替醚键旋转的材料关系。此外，三氯生与二次键合的键缠结会在需要柔韧性的弱细菌脂质膜中产生结构缺陷，进而干扰细胞分裂。关于聚合物的应用，三氯生可以在固化前通过混合加入树脂体系中，与热塑性聚合物熔融混合，冷却后固化成固体，或者通过几种不同的方法作为涂层应用，例如溶解在有机溶剂中，通过蒸发干燥作为常用方法。
