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含三氯生聚合物复合材料的抗菌和抗病毒特性:pH值、紫外线及阳光照射的老化影响

Antimicrobial and Antiviral Properties of Triclosan-Containing Polymer Composite: Aging Effects of pH, UV, and Sunlight Exposure.

作者信息

Tauanov Zhandos, Zakiruly Olzhas, Baimenova Zhuldyz, Baimenov Alzhan, Akimbekov Nuraly S, Berillo Dmitriy

机构信息

Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.

Department of Research and Development, LLP "Marmar Kazakhstan", Taldykorgan 040008, Kazakhstan.

出版信息

Polymers (Basel). 2023 Feb 28;15(5):1236. doi: 10.3390/polym15051236.

Abstract

The present study deals with the synthesis and characterization of a polymer composite based on an unsaturated ester loaded with 5 wt.% triclosan, produced by co-mixing on an automated hardware system. The polymer composite's non-porous structure and chemical composition make it an ideal material for surface disinfection and antimicrobial protection. According to the findings, the polymer composite effectively inhibited (100%) the growth of 6538-P under exposure to physicochemical factors, including pH, UV, and sunlight, over a 2-month period. In addition, the polymer composite demonstrated potent antiviral activity against human influenza virus strain A and the avian coronavirus infectious bronchitis virus (IBV), with infectious activities of 99.99% and 90%, respectively. Thus, the resulting triclosan-loaded polymer composite is revealed to have a high potential as a surface-coating non-porous material with antimicrobial properties.

摘要

本研究涉及一种基于负载5 wt.%三氯生的不饱和酯的聚合物复合材料的合成与表征,该复合材料通过在自动化硬件系统上共混制备而成。该聚合物复合材料的无孔结构和化学成分使其成为表面消毒和抗菌防护的理想材料。研究结果表明,在为期2个月的时间里,该聚合物复合材料在暴露于包括pH值、紫外线和阳光等物理化学因素的情况下,能有效抑制(100%)6538-P菌的生长。此外,该聚合物复合材料对人类甲型流感病毒株和禽冠状病毒传染性支气管炎病毒(IBV)表现出强大的抗病毒活性,其感染活性分别为99.99%和90%。因此,所制备的负载三氯生的聚合物复合材料显示出作为具有抗菌性能的表面涂层无孔材料的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/362d/10007459/464586673735/polymers-15-01236-g001.jpg

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