Bunyaratavej P, Wang H L
Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA.
J Periodontol. 2001 Feb;72(2):215-29. doi: 10.1902/jop.2001.72.2.215.
Collagen materials have been utilized in medicine and dentistry because of their proven biocompatability and capability of promoting wound healing. For guided tissue regeneration (GTR) procedures, collagen membranes have been shown to be comparable to non-absorbable membranes with regard to probing depth reduction, clinical attachment gain, and percent of bone fill. Although these membranes are absorbable, collagen membranes have been demonstrated to prevent epithelial down-growth along the root surfaces during the early phase of wound healing. The use of grafting material in combination with collagen membranes seems to improve clinical outcomes for furcation, but not intrabony, defects when compared to the use of membranes alone. Recently, collagen materials have also been applied in guided bone regeneration (GBR) and root coverage procedures with comparable success rates to non-absorbable expanded polytetrafluoroethylene (ePTFE) membranes and conventional subepithelial connective tissue grafts, respectively. Long-term clinical trials are still needed to further evaluate the benefits of collagen membranes in periodontal and peri-implant defects. This article will review the rationale for each indication and its related literature, both in vitro and in vivo studies. The properties that make collagen membranes attractive for use in regenerative therapy will be addressed. In addition, varieties of cross-linking techniques utilized to retard the degradation rate of collagen membranes will be discussed.
胶原蛋白材料因其已被证实的生物相容性和促进伤口愈合的能力，已被应用于医学和牙科领域。对于引导组织再生（GTR）手术，在探诊深度降低、临床附着增加和骨填充百分比方面，胶原蛋白膜已被证明与不可吸收膜相当。尽管这些膜是可吸收的，但胶原蛋白膜已被证明在伤口愈合早期可防止上皮沿根面生长。与单独使用膜相比，将移植材料与胶原蛋白膜联合使用似乎可改善根分叉缺损的临床效果，但对骨内缺损无效。最近，胶原蛋白材料也已分别应用于引导骨再生（GBR）和牙根覆盖手术，成功率与不可吸收膨胀聚四氟乙烯（ePTFE）膜和传统上皮下结缔组织移植相当。仍需要长期临床试验来进一步评估胶原蛋白膜在牙周和种植体周围缺损中的益处。本文将综述每种适应症的理论依据及其相关文献，包括体外和体内研究。还将探讨使胶原蛋白膜在再生治疗中具有吸引力的特性。此外，还将讨论用于延缓胶原蛋白膜降解速率的各种交联技术。
