Dupoirieux L, Pourquier D, Picot M C, Neves M
Institute of Surgical Research, Montpellier, France.
Int J Oral Maxillofac Surg. 2001 Feb;30(1):58-62. doi: 10.1054/ijom.2000.0011.
The purpose of the study was to compare the efficacy of a non-resorbable polytetrafluoroethylene (e-PTFE) membrane (Gore-Tex) versus a resorbable polyglactin membrane (Vicryl) and a newly designed collagenic membrane for enhancing bone regeneration on rat skull defects. The study was conducted on 30 adult Wistar rats. On each animal, two symmetrical, 6 mm wide, full-thickness, skull defects were created in the parietal regions. The right defect was chosen as the experimental site and the left one was left empty as a control. Each experimental site was covered by an inner and outer membrane. The 30 rats were divided into three groups: In group 1 (n=10), a non-resorbable polytetrafluoroethylene (e-PTFE) membrane was used. In group 2 (n= 10), a resorbable polyglactin 910 membrane was used. In group 3 (n= 10), a collagen membrane processed from avian eggshell was used. In each group, the animals were euthanized at 60 days. The harvested specimens were processed for contact radiography and standard histological examination. The results were assessed by a Fisher's exact test. In group 1, partial bone healing was observed in seven out of 10 animals and complete in three out of 10 animals (P<0.001). In group 2, no or minimal bone healing was observed in seven out of 10 animals and partial bone healing was observed in three out of 10 animals. In group 3, no or minimal bone healing was observed in nine out of 10 cases and partial bone healing in only one animal. In conclusion, only the non-resorbable e-PTFE membrane group exhibited a favourable result in this study. This study suggests that the structure of the membrane is at least as important as its composition.
本研究的目的是比较不可吸收的聚四氟乙烯（e-PTFE）膜（戈尔特斯）与可吸收的聚乙交酯膜（薇乔）以及一种新设计的胶原膜在促进大鼠颅骨缺损骨再生方面的疗效。该研究对30只成年Wistar大鼠进行。在每只动物的顶叶区域制造两个对称的、6毫米宽的全层颅骨缺损。右侧缺损作为实验部位，左侧缺损空置作为对照。每个实验部位覆盖一层内膜和一层外膜。30只大鼠分为三组：第1组（n = 10）使用不可吸收的聚四氟乙烯（e-PTFE）膜；第2组（n = 10）使用可吸收的聚乙交酯910膜；第3组（n = 10）使用由鸡蛋壳加工而成的胶原膜。每组动物在60天时实施安乐死。对收获的标本进行接触式放射摄影和标准组织学检查。结果通过Fisher精确检验进行评估。在第1组中，10只动物中有7只观察到部分骨愈合，10只动物中有3只完全愈合（P<0.001）。在第2组中，10只动物中有7只未观察到或仅有极少骨愈合，10只动物中有3只观察到部分骨愈合。在第3组中，10例中有9例未观察到或仅有极少骨愈合，仅1只动物出现部分骨愈合。总之，在本研究中只有不可吸收的e-PTFE膜组呈现出良好结果。本研究表明，膜的结构至少与其成分同样重要。
