Bizelli Vinícius Ferreira, Alécio Viotto Arthur Henrique, Delamura Izabela Fornazari, Baggio Ana Maira Pereira, Ramos Edith Umasi, Faverani Leonardo Perez, Bassi Ana Paula Farnezi
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University, UNESP, Araçatuba 16015-050, SP, Brazil.
Biomimetics (Basel). 2024 Jul 16;9(7):431. doi: 10.3390/biomimetics9070431.
Guided bone regeneration (GBR) has become a necessary practice in implantology. Absorbable membranes have shown advantages over non-absorbable membranes, such as blood support of bone tissue. This study aimed to evaluate five collagen membranes in rat calvaria critical-size defects through a histomorphometric analysis of the inflammatory profile during the initial phase of bone repair.
A total of 72 Albinus Wistar rats were used for the study, divided into six groups, with 12 animals per group, and two experimental periods, 7 and 15 days. The groups were as follows: the CG (clot), BG (Bio-Gide), JS (Jason), CS (Collprotect), GD (GemDerm), and GDF (GemDerm Flex).
Data showed that the BG group demonstrated an inflammatory profile with an ideal number of inflammatory cells and blood vessels, indicating a statistically significant difference between the JS and CS groups and the BG group in terms of the number of inflammatory cells and a statistically significant difference between the JS and CS groups and the GD group in terms of angiogenesis ( < 0.05).
We conclude that different origins and ways of obtaining them, as well as the thickness of the membrane, can interfere with the biological response of the material.
引导骨再生（GBR）已成为种植牙学中的一项必要操作。可吸收膜已显示出优于不可吸收膜的优势，例如对骨组织的血液支持。本研究旨在通过对骨修复初始阶段炎症特征的组织形态计量学分析，评估大鼠颅骨临界尺寸缺损中的五种胶原膜。
总共72只白化Wistar大鼠用于该研究，分为六组，每组12只动物，并设置两个实验期，分别为7天和15天。分组如下：CG（血凝块）组、BG（Bio-Gide）组、JS（Jason）组、CS（Collprotect）组、GD（GemDerm）组和GDF（GemDerm Flex）组。
数据显示，BG组呈现出具有理想数量炎症细胞和血管的炎症特征，表明JS组和CS组与BG组在炎症细胞数量方面存在统计学显著差异，且JS组和CS组与GD组在血管生成方面存在统计学显著差异（P<0.05）。
我们得出结论，不同的来源、获取方式以及膜的厚度会干扰材料的生物学反应。
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