Michalek S M, Rahman A F, McGhee J R
Proc Soc Exp Biol Med. 1975 Apr;148(4):1114-8. doi: 10.3181/00379727-148-38699.
Immunoglobulin levels in colostrum and milk of normal and protein malnourished rat dams and in serum and saliva of their offspring were quantitated by radial immunodiffusion employing purified anti-rat alpha, gamma and mu. In general, no significant difference was observed in the level of colostral IgA in malnourished as compared to normal rat dams or in the level of serum IgA and IgM and salivary IgA and IgG2a of their offspring. On the other hand, malnourished mothers demonstrated approximately twofold lower levels of colostral IgG2a than normal mothers throughout the entire period of lactation. In addition, at every interval tested, the level of IgG was approximately 1.5- to 2-fold less in malnourished as compared to normal offspring.
采用纯化的抗大鼠α、γ和μ免疫球蛋白，通过单向免疫扩散法定量检测正常和蛋白质营养不良大鼠母鼠初乳和乳汁中以及它们后代血清和唾液中的免疫球蛋白水平。总体而言，与正常大鼠母鼠相比，营养不良大鼠母鼠初乳中IgA水平，或其后代血清IgA和IgM水平以及唾液IgA和IgG2a水平均未观察到显著差异。另一方面，在整个哺乳期，营养不良的母鼠初乳中IgG2a水平比正常母鼠低约两倍。此外，在每个测试时间间隔，与正常后代相比，营养不良后代的IgG水平低约1.5至2倍。
