耐万古霉素肠球菌的出现。
Emergence of vancomycin-resistant enterococci.
作者信息
Rice L B
机构信息
VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
出版信息
Emerg Infect Dis. 2001 Mar-Apr;7(2):183-7. doi: 10.3201/eid0702.010205.
Abstract
Vancomycin and ampicillin resistance in clinical Enterococcus faecium strains has developed in the past decade. Failure to adhere to strict infection control to prevent the spread of these pathogens has been well established. New data implicate the use of specific classes of antimicrobial agents in the spread of vancomycin-resistant enterococci (VRE). Extended-spectrum cephalosporins and drugs with potent activity against anaerobic bacteria may promote infection and colonization with VRE and may exert different effects on the initial establishment and persistence of high-density colonization. Control of VRE will require better understanding of the mechanisms by which different classes of drugs promote gastrointestinal colonization.
摘要
在过去十年中，临床粪肠球菌菌株已出现对万古霉素和氨苄西林的耐药性。未能严格遵守感染控制措施以防止这些病原体传播的情况已得到充分证实。新数据表明，特定类别的抗菌药物的使用与耐万古霉素肠球菌（VRE）的传播有关。广谱头孢菌素和对厌氧菌具有强效活性的药物可能会促进VRE的感染和定植，并且可能对高密度定植的初始建立和持续存在产生不同影响。控制VRE将需要更好地了解不同类药物促进胃肠道定植的机制。
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