Wang Bo, Chen Sen, Sun Xuyang, Shan Xiaohui, Zhu Xiyu, Yuan Bo, Wang Hongzhang, Zhou Gang, Liu Jing
School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Bioengineering (Basel). 2023 Jun 22;10(7):748. doi: 10.3390/bioengineering10070748.
The targeted antimicrobial efficacy of Vancomycin decreases significantly over time due to bacterial resistance, whereas Ga-based liquid metals, which are less prone to inducing bacterial resistance, face challenges in achieving targeted antimicrobial effects. To tackle these issues, a highly efficient antimicrobial agent with targeting properties has been developed by combining Ga-based liquid metals and Vancomycin. Moreover, the performance of this antimicrobial agent can be greatly enhanced through the use of near-infrared light. Microscopic observations reveal that Vancomycin can be effectively encapsulated on the surface of liquid metal, facilitated by the presence of the oxide layer. The resulting core-shell structured antimicrobial agent demonstrates notable targeted antimicrobial effects against . Antibacterial tests indicate that Vancomycin effectively improves the antibacterial properties of pure liquid metal. Additionally, this study unveils the excellent photothermal conversion capabilities of liquid metal, enabling the antimicrobial agent exposed to 808nm near-infrared light to exhibit significantly strengthened bactericidal performance. In this scenario, the antimicrobial agent can achieve nearly 100% effectiveness. This work enriches the investigation of integrating Ga-based antimicrobial agents with traditional antibiotics, showcasing promising antibacterial effects and establishing the groundwork for subsequent clinical applications.
由于细菌耐药性，万古霉素的靶向抗菌效果会随着时间显著下降，而不易诱导细菌耐药的镓基液态金属在实现靶向抗菌效果方面面临挑战。为了解决这些问题，通过将镓基液态金属与万古霉素结合，开发出了一种具有靶向特性的高效抗菌剂。此外，通过使用近红外光，这种抗菌剂的性能可以得到极大提升。显微镜观察表明，在氧化层的作用下，万古霉素能够有效地包裹在液态金属表面。由此形成的核壳结构抗菌剂对……显示出显著的靶向抗菌效果。抗菌测试表明，万古霉素有效地提高了纯液态金属的抗菌性能。此外，这项研究揭示了液态金属出色的光热转换能力，使得暴露于808nm近红外光下的抗菌剂展现出显著增强的杀菌性能。在这种情况下，抗菌剂可实现近100%的有效性。这项工作丰富了镓基抗菌剂与传统抗生素相结合的研究，展示了有前景的抗菌效果，并为后续临床应用奠定了基础。
