Brown J M, Probert J C
Radiology. 1975 Jun;115(3):711-6. doi: 10.1148/15.3.711.
The effect of two 10-fraction courses of irradiation separated by intervals varying from 1 to 10 months on both the early skin reaction and late deformity of the leg was studied in mice. It was found that the "memory" of the first course was much greater for the late end point (deformity) than for early skin reactions at all intervals between the two courses. The extent of the late deformity reaction following a second course was predicted fairly well from the Ellis formula for decay of partial tolerance, but it also appeared to be more complex than is evident from the formula. Evaluation of early vs. late reactions showed that the extent of the deformity is not governed entirely by the level of the early skin reaction; rather, it depends critically on the previous radiation history of the tissue.
在小鼠中研究了两个疗程、每个疗程10次照射，间隔时间从1个月到10个月不等，对早期皮肤反应和腿部晚期畸形的影响。结果发现，对于两个疗程之间的所有间隔时间，第一个疗程对晚期终点（畸形）的“记忆”比对早期皮肤反应的“记忆”要强得多。根据埃利斯部分耐受性衰减公式，可以较好地预测第二个疗程后晚期畸形反应的程度，但实际情况似乎比公式所显示的更为复杂。对早期反应与晚期反应的评估表明，畸形的程度并非完全由早期皮肤反应的程度决定；相反，它关键取决于组织先前的辐射史。
