Perry A M, Hamlet R, Kirk J
Br J Cancer. 1979 Oct;40(4):649-57. doi: 10.1038/bjc.1979.231.
The cumulative radiation effect (CRE) is one of several empirical scalar descriptions of biological effect which enable corrections to be made for gaps in radiotherapy treatment. Predictions of this theory were tested using mouse crypt regeneration and mouse skin as biological models. These experimental results are discussed in terms of the dependence of tissue regeneration potential during a gap on the biological effect achieved before the gap, and on gap length. A hypothesis is proposed to reconcile the apparent conflict between the two experiments. While the simple exponential gap formulation of the CRE is seen to be inadequate, insufficient data are available at present to modify it.
累积辐射效应（CRE）是对生物效应的几种经验性标量描述之一，它能够对放射治疗中的间隙进行校正。该理论的预测通过使用小鼠隐窝再生和小鼠皮肤作为生物学模型进行了测试。根据间隙期间组织再生潜力对间隙前达到的生物效应以及间隙长度的依赖性来讨论这些实验结果。提出了一个假设来调和两个实验之间明显的冲突。虽然CRE的简单指数间隙公式被认为是不充分的，但目前可用的数据不足以对其进行修改。
