Lualdi M, Colombo A, Farina B, Tomatis S, Marchesini R
Medical Physics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Lasers Surg Med. 2001;28(3):237-43. doi: 10.1002/lsm.1044.
Modeling of light transport in tissue requires development of theoretical models and experimental procedures, as well as tissue-simulating phantoms. Our purpose was to develop a phantom that matches the optical characteristics of human skin in the visible and near infrared spectral range.
STUDY DESIGN/MATERIALS AND METHODS: The phantom consists of a transparent silicone rubber in which Al(2)O(3) particles and a cosmetic powder are embedded. Layers with thickness as thin as 0.1 mm can be made. The optical properties of Al(2)O(3) particles and cosmetic powder, i.e., total attenuation, absorption and scattering coefficients, and phase function, have been determined in the visible and near infrared spectral range, by using direct and indirect techniques.
By varying the concentration of scattering and absorbing particles, tissue-like layers can be produced with predictable optical properties. In particular, mixing at suitable concentration Al(2)O(3) particles and cosmetic powder with the silicone rubber, the optical properties of human skin have been simulated over a range of wavelengths from 400 to 1,000 nm. The comparison between the phantom diffuse reflectance spectrum and that of human skin, averaged over a sample of 260 patients, showed a good agreement.
The proposed technique allows to produce a stable and reproducible phantom, with accurately predictable optical properties, easy to make and to handle. This phantom is a useful tool for numerous applications involving light interaction with biologic tissue.
组织中光传输的建模需要开发理论模型、实验程序以及组织模拟体模。我们的目的是开发一种在可见光和近红外光谱范围内与人体皮肤光学特性相匹配的体模。
研究设计/材料与方法：该体模由一种透明硅橡胶组成，其中嵌入了Al₂O₃颗粒和一种化妆粉。可以制作出厚度薄至0.1毫米的层。通过直接和间接技术，已在可见光和近红外光谱范围内测定了Al₂O₃颗粒和化妆粉的光学特性，即总衰减、吸收和散射系数以及相位函数。
通过改变散射和吸收颗粒的浓度，可以生产出具有可预测光学特性的类似组织的层。特别是，将Al₂O₃颗粒和化妆粉以合适的浓度与硅橡胶混合，在400至1000纳米的波长范围内模拟了人体皮肤的光学特性。对260名患者样本的体模漫反射光谱与人体皮肤漫反射光谱进行比较，结果显示吻合良好。
所提出的技术能够生产出一种稳定且可重复的体模，其光学特性具有准确的可预测性，易于制作和操作。这种体模是用于众多涉及光与生物组织相互作用应用的有用工具。
