Shields J A, Shields C L, Eagle R C, Singh A D
Oncology Service, Wills Eye Hospital, 900 Walnut St, Philadelphia, PA 19107, USA.
Arch Ophthalmol. 2001 Apr;119(4):597-602. doi: 10.1001/archopht.119.4.597.
Congenital hypertrophy of the retinal pigment epithelium (CHRPE), traditionally regarded as a benign stationary condition, has recently been shown in 5 cases to give rise to an elevated, solid tumor. However, the histopathologic nature of the tumor that arises from CHRPE has not been previously determined. A 65-year-old woman developed a progressively enlarging peripheral fundus tumor that arose from a focus of classic CHRPE. The tumor produced a localized exudative retinal detachment, cystoid macular edema, and surface-wrinkling retinopathy. The mass was removed by local resection, and histopathologic examination revealed a low-grade adenocarcinoma of the retinal pigment epithelium, apparently arising from CHRPE. Although CHRPE is usually a benign nonprogressive lesion, it can give rise to a malignant tumor. Congenital hypertrophy of the retinal pigment epithelium should be observed periodically for development of a neoplasm.
视网膜色素上皮先天性肥大（CHRPE），传统上被视为一种良性静止性病症，最近在5例病例中显示会引发一种隆起的实性肿瘤。然而，此前尚未确定由CHRPE引发的肿瘤的组织病理学性质。一名65岁女性出现了一个由典型CHRPE病灶引发的逐渐增大的周边眼底肿瘤。该肿瘤导致了局限性渗出性视网膜脱离、黄斑囊样水肿和视网膜表面皱缩病变。通过局部切除将肿块移除，组织病理学检查显示为视网膜色素上皮的低级别腺癌，显然源自CHRPE。尽管CHRPE通常是一种良性非进展性病变，但它可引发恶性肿瘤。应对视网膜色素上皮先天性肥大进行定期观察，以监测肿瘤的发生。
