Moore S
The Centre for Cancer and Palliative Care Studies, Institute of Cancer Research, Sutton, Surrey, UK.
J Adv Nurs. 2001 Mar;33(6):738-47. doi: 10.1046/j.1365-2648.2001.01715.x.
The area of phase I trials is fraught with ethical dilemmas and controversy. Most existing research focuses on issues of human rights and the informed consent procedure. Little attention has been given to patients' perceptions of participating in such trials.
This paper describes a study using qualitative interviews and open-stem questionnaires to begin to explore patients' own perceptions of any benefits from participating in phase I trials.
Findings suggest that for some patients, phase I trials fulfil a need to try everything in their fight against cancer. The study also suggests that being on treatment allows some patients to construct their lives meaningfully by providing a supportive structure and enabling hope. Implications for nursing practice and further research are discussed.
一期试验领域充满了伦理困境和争议。现有的大多数研究都集中在人权问题和知情同意程序上。很少有人关注患者对参与此类试验的看法。
本文描述了一项研究，该研究使用定性访谈和开放式问卷来初步探索患者对参与一期试验所获益处的自身看法。
研究结果表明，对一些患者来说，一期试验满足了他们在抗癌斗争中尝试一切的需求。该研究还表明，接受治疗能为一些患者提供支持性结构并带来希望，从而使他们能够有意义地构建自己的生活。文中讨论了对护理实践和进一步研究的启示。
