Erasmus MC Cancer Institute, Department of Medical Oncology, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Support Care Cancer. 2023 Apr 21;31(5):290. doi: 10.1007/s00520-023-07738-y.
Until today, it is not clear why patients decide to continue with early clinical trial (ECT) participation. Therefore, the aim of this study is to explore to which extent the self-determination theory of Ryan and Deci, according to the ECT enrollment phase, corresponds to the motivations of participants during ECT's.
This study has a qualitative design. Data were collected using semistructured interviews and were deductively analyzed in Nvivo12 using the thematic analysis approach of Braun and Clarke.
As a result of the deductive analysis performed, six themes and twenty subthemes emerged which matched the three personal needs: competence, relatedness, and autonomy (n = 11). "Competence" included the following themes: mixed future expectations, treatment expectations, and control of the outcome. "Relatedness" included the theme altruistic motivation. "Autonomy" included the themes; to live and act in harmony as well as mental and physical burden.
Participants felt they tried everything and that they were treated to the limit. This not only gives the motivation to continue participating but also a sense of altruism. Despite different burdens, side-effects, and the feeling of being a test subject, the participants will not easily choose to stop participation in order to prevent saying afterwards: "If only I had".
直到今天，为什么患者决定继续参与早期临床试验（ECT）仍不清楚。因此，本研究旨在探讨 Ryan 和 Deci 的自我决定理论在多大程度上符合 ECT 期间参与者的动机，根据 ECT 的入组阶段进行划分。
本研究采用定性设计。使用半结构式访谈收集数据，并使用 Nvivo12 中的 Braun 和 Clarke 的主题分析方法进行演绎分析。
由于进行了演绎分析，出现了六个主题和二十个子主题，这些主题符合三个个人需求：能力、关联性和自主性（n=11）。“能力”包括以下主题：混合的未来期望、治疗期望和对结果的控制。“关联性”包括利他动机这一主题。“自主性”包括“生活和行动和谐”以及“身心负担”这两个主题。
参与者感到他们已经尝试了一切，并且已经被治疗到了极限。这不仅给了他们继续参与的动力，也给了他们一种利他主义的感觉。尽管存在不同的负担、副作用和作为试验对象的感觉，参与者不会轻易选择停止参与，以免事后后悔：“要是我当初……就好了”。
