Scheja A, Akesson A, Geborek P, Wildt M, Wollheim C B, Wollheim F A, Vischer U M
Department of Rheumatology, University Hospital, Lund, Sweden.
Arthritis Res. 2001;3(3):178-82. doi: 10.1186/ar295. Epub 2001 Feb 19.
In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
在44例连续性系统性硬化症（SSc）患者中，血管性血友病因子（vWf）的血浆浓度高于其前肽，但前肽在患者亚组中的变异性较小。在早期肺部受累的患者中观察到前肽水平较高。前肽与活性生化标志物的相关性也比vWf更密切。我们的结果表明，尽管前肽的循环半衰期比vWf短，血浆浓度也比vWf低，但在评估SSc的疾病活动方面更有用。
